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Tbio
ATP6V1H
V-type proton ATPase subunit H

Protein Summary
Description
Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates the ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system (By similarity). Involved in the endocytosis mediated by clathrin-coated pits, required for the formation of endosomes. This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular organelles. V-ATPase-dependent organelle acidification is necessary for multiple processes including protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. The encoded protein is the regulatory H subunit of the V1 domain of V-ATPase, which is required for catalysis of ATP but not the assembly of V-ATPase. Decreased expression of this ge ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000355221
  • ENSP00000347359
  • ENSG00000047249
  • ENST00000359530
  • ENSP00000352522
  • ENST00000396774
  • ENSP00000379995

Symbol
  • SFD
  • NBP1
  • VMA13
  • CGI-11
  • MSTP042
  • SFDbeta
  • SFDalpha
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.98
molecular function
0.96
transcription factor perturbation
0.94
disease perturbation
0.9
kinase perturbation
0.84


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.61   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 139   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.61   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 139   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ATPase H+ transporting V1 subunit H
VGNC:7588
740229
Macaque
ATPase H+ transporting V1 subunit H
693323
Mouse
MGI:1914864
108664
Rat
RGD:1562450
297797
Dog
ATPase H+ transporting V1 subunit H
VGNC:38284
486953
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ATPase H+ transporting V1 subunit H
Macaque
ATPase H+ transporting V1 subunit H
Mouse
Rat
Dog
ATPase H+ transporting V1 subunit H
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9UI12-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (30)
Disease (R-HSA-1643685)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 19
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disease
Reactome
HIV Infection
Reactome
Host Interactions of HIV factors
Reactome
Immune System
Reactome
Infectious disease
Name
Explore in Pharos
Explore in Source
Disease
HIV Infection
Host Interactions of HIV factors
Immune System
Infectious disease
Protein-Protein Interactions (102)
1 – 10 of 102
MAS1
Tchem
Family: GPCR
Novelty: 0.0089712
p_int: 0.883702859
p_ni: 0.116297141
Score: 0.187
Data Source: BioPlex,STRINGDB
ATP6V1D
Tbio
Family: Enzyme
Novelty: 0.02298626
Score: 0.999
Data Source: STRINGDB
ATP6V1A
Tbio
Family: Enzyme
Novelty: 0.00921474
Score: 0.999
Data Source: STRINGDB
ATP6V1E1
Tbio
Family: Enzyme
Novelty: 0.04832113
Score: 0.999
Data Source: STRINGDB
ATP6V1B2
Tchem
Family: Enzyme
Novelty: 0.01767911
Score: 0.999
Data Source: STRINGDB
ATP6V1F
Tbio
Family: Enzyme
Novelty: 0.07109314
Score: 0.999
Data Source: STRINGDB
ATP6V1C1
Tbio
Family: Enzyme
Novelty: 0.03660846
Score: 0.998
Data Source: STRINGDB
ATP6V1E2
Tbio
Family: Enzyme
Novelty: 0.10447007
Score: 0.998
Data Source: STRINGDB
ATP6V1C2
Tbio
Family: Enzyme
Novelty: 0.07583427
Score: 0.998
Data Source: STRINGDB
ATP6V0D1
Tbio
Family: Enzyme
Novelty: 0.05146108
Score: 0.997
Data Source: STRINGDB
Publication Statistics
PubMed Score  25.61

PubMed score by year
PubTator Score  8.06

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer