Tbio EIF2B4 Translation initiation factor eIF-2B subunit delta

Protein Summary

Description

Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP. Eukaryotic initiation factor 2B (EIF2B), which is necessary for protein synthesis, is a GTP exchange factor composed of five different subunits. The protein encoded by this gene is the fourth, or delta, subunit. Defects in this gene are a cause of leukoencephalopathy with vanishing white matter (VWM) and ovarioleukodystrophy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9UI10
• Q53RY7
• Q5BJF4
• Q9BUV9
• Q9UBG4
• Q9UIQ9
• Q9UJ95

Gene Name

• EIF2B4

Ensembl ID

• ENST00000347454
• ENSP00000233552
• ENSG00000115211
• ENST00000445933
• ENSP00000394397
• ENST00000451130
• ENSP00000394869

Symbol

• EIF2BD
• EIF2B
• EIF-2B
• EIF2Bdelta

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.99
kinase perturbation	0.99
interacting protein	0.97
biological process	0.86
transcription factor binding site profile	0.85

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.47   (req: < 5)

Gene RIFs: 19   (req: <= 3)

Antibodies: 179   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.47   (req: >= 5)

Gene RIFs: 19   (req: > 3)

Antibodies: 179   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0