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Tbio
EIF2B4
Translation initiation factor eIF-2B subunit delta

Protein Summary
Description
Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP. Eukaryotic initiation factor 2B (EIF2B), which is necessary for protein synthesis, is a GTP exchange factor composed of five different subunits. The protein encoded by this gene is the fourth, or delta, subunit. Defects in this gene are a cause of leukoencephalopathy with vanishing white matter (VWM) and ovarioleukodystrophy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000347454
  • ENSP00000233552
  • ENSG00000115211
  • ENST00000445933
  • ENSP00000394397
  • ENST00000451130
  • ENSP00000394869

Symbol
  • EIF2BD
  • EIF2B
  • EIF-2B
  • EIF2Bdelta
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.99
kinase perturbation
0.99
interacting protein
0.97
biological process
0.86
transcription factor binding site profile
0.85


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.39   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 179   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.39   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 179   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (27)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
9
17
28
99.9
C-reactive protein measurement
1
6
6
98
serum gamma-glutamyl transferase measurement
1
5
5
96.7
total cholesterol measurement
3
6
4
3.9
96.5
urate measurement
1
4
4
95.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
28
99.9
C-reactive protein measurement
6
98
serum gamma-glutamyl transferase measurement
5
96.7
total cholesterol measurement
4
3.9
96.5
urate measurement
4
95.6
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
eukaryotic translation initiation factor 2B subunit delta
VGNC:2930
459099
Macaque
eukaryotic translation initiation factor 2B subunit delta
700322
Mouse
MGI:95300
13667
Rat
RGD:620208
117019
Dog
eukaryotic translation initiation factor 2B subunit delta
VGNC:40263
475702
Species
Name
OMA
EggNOG
Inparanoid
Chimp
eukaryotic translation initiation factor 2B subunit delta
Macaque
eukaryotic translation initiation factor 2B subunit delta
Mouse
Rat
Dog
eukaryotic translation initiation factor 2B subunit delta
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9UI10-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (8)
Cap-dependent Translation Initiation (R-HSA-72737)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cap-dependent Translation Initiation
Reactome
Eukaryotic Translation Initiation
Reactome
Metabolism of proteins
Reactome
Recycling of eIF2:GDP
Reactome
Translation
Name
Explore in Pharos
Explore in Source
Cap-dependent Translation Initiation
Eukaryotic Translation Initiation
Metabolism of proteins
Recycling of eIF2:GDP
Translation
Protein-Protein Interactions (108)
1 – 10 of 108
EIF2B2
Tbio
Novelty:  0.03253919
p_int:  0.999998801
p_ni:  0.000001199
Score:  0.996
Data Source:  BioPlex,STRINGDB
EIF2B5
Tbio
Novelty:  0.0102209
p_int:  0.999996792
p_ni:  0.000003208
Score:  0.999
Data Source:  BioPlex,STRINGDB
GYPB
Tbio
Novelty:  0.00442195
p_int:  0.999946789
p_ni:  0.000053211
Data Source:  BioPlex
BTC
Tbio
Novelty:  0.00673076
p_int:  0.999929358
p_ni:  0.000070642
Data Source:  BioPlex
CD226
Tbio
Novelty:  0.00374102
p_int:  0.999722925
p_ni:  0.000277075
Data Source:  BioPlex
GPR183
Tchem
Family:  GPCR
Novelty:  0.02005679
p_int:  0.998587495
p_ni:  0.001412505
Data Source:  BioPlex
SIGLECL1
Tdark
p_int:  0.997420454
p_ni:  0.002579546
Data Source:  BioPlex
CA14
Tclin
Family:  Enzyme
Novelty:  0.00864764
p_int:  0.992883128
p_ni:  0.007116872
Data Source:  BioPlex
CLEC2B
Tbio
Novelty:  0.06581244
p_int:  0.989471849
p_ni:  0.010528151
Data Source:  BioPlex
EIF2B1
Tbio
Novelty:  0.02520554
p_int:  0.984004614
p_ni:  0.015995386
Score:  0.991
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  17.39

PubMed score by year
PubTator Score  91.55

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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