You are using an outdated browser. Please upgrade your browser to improve your experience.

Tclin
NDUFA12
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12

Protein Summary
Description
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. This gene encodes a protein which is part of mitochondrial complex 1, part of the oxidative phosphorylation system in mitochondria. Complex 1 transfers electrons to ubiquinone from NADH which establishes a proton gradient for the generation of ATP. Mutations in this gene are associated with Leigh syndrome due to mitochondrial complex 1 deficiency. Pseudogenes of this gene are located on chromosomes 5 and 13. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000327772
  • ENSP00000330737
  • ENSG00000184752
  • ENST00000547986
  • ENSP00000450130

Symbol
  • DAP13
  • B17.2
  • DAP13
  • MC1DN23
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
histone modification site profile
0.91
small molecule perturbation
0.9
transcription factor perturbation
0.88
disease perturbation
0.83


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.27   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 159   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.27   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 159   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (171)
NDUFB11
Tclin
Family:  Enzyme
Novelty:  0.0401232
p_int:  0.999999299
p_ni:  7.01e-7
Score:  0.998
Data Source:  BioPlex,STRINGDB
NDUFS3
Tclin
Family:  Enzyme
Novelty:  0.01968313
p_int:  0.999998038
p_ni:  0.000001962
Score:  0.999
Data Source:  BioPlex,STRINGDB
NDUFA8
Tclin
Family:  Enzyme
Novelty:  0.05772867
p_int:  0.999995528
p_ni:  0.000004472
Score:  0.999
Data Source:  BioPlex,STRINGDB
GPIHBP1
Tbio
Novelty:  0.01241227
p_int:  0.999955221
p_ni:  0.000016789
p_wrong:  0.00002799
Data Source:  BioPlex
NDUFA9
Tclin
Family:  Enzyme
Novelty:  0.00637307
p_int:  0.999768314
p_ni:  0.000231686
Score:  0.999
Data Source:  BioPlex,STRINGDB
NDUFS5
Tclin
Family:  Enzyme
Novelty:  0.13274675
p_int:  0.999717458
p_ni:  0.000282542
Score:  0.999
Data Source:  BioPlex,STRINGDB
NDUFA7
Tclin
Family:  Enzyme
Novelty:  0.16417588
p_int:  0.999695186
p_ni:  0.00030456
p_wrong:  2.55e-7
Score:  0.999
Data Source:  BioPlex,STRINGDB
IL1R2
Tbio
Novelty:  0.00820359
p_int:  0.999641547
p_ni:  0.000358453
Data Source:  BioPlex
NDUFS4
Tclin
Family:  Enzyme
Novelty:  0.00787292
p_int:  0.999410246
p_ni:  0.000521654
p_wrong:  0.000068101
Score:  0.999
Data Source:  BioPlex,STRINGDB
NDUFS7
Tclin
Family:  Enzyme
Novelty:  0.01562198
p_int:  0.99853548
p_ni:  0.00146452
Score:  0.999
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (16)
Complex I biogenesis (R-HSA-6799198)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Complex I biogenesis
Reactome
Metabolism
Reactome
Respiratory electron transport
Reactome
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
Reactome
The citric acid (TCA) cycle and respiratory electron transport
Name
Explore in Pharos
Explore in Source
Complex I biogenesis
Metabolism
Respiratory electron transport
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
The citric acid (TCA) cycle and respiratory electron transport
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
2
2
72.1
4
4
2
1.1
70
pulse pressure measurement
1
1
1
59.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
72.1
2
1.1
70
pulse pressure measurement
1
59.5
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NADH:ubiquinone oxidoreductase subunit A12
VGNC:5498
452134
Macaque
NADH:ubiquinone oxidoreductase subunit A12
711970
Mouse
MGI:1913664
66414
Rat
RGD:1311462
299739
Dog
NADH:ubiquinone oxidoreductase subunit A12
VGNC:43685
475428
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NADH:ubiquinone oxidoreductase subunit A12
Macaque
NADH:ubiquinone oxidoreductase subunit A12
Mouse
Rat
Dog
NADH:ubiquinone oxidoreductase subunit A12
Publication Statistics
PubMed Score 20.27
PubMed score by year
PubTator Score 4.04
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title