You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
EVL
Ena/VASP-like protein

Protein Summary
Description
Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. EVL enhances actin nucleation and polymerization.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000392920
  • ENSP00000376652
  • ENSG00000196405
  • ENST00000402714
  • ENSP00000384720
  • ENST00000544450
  • ENSP00000437904

Symbol
  • RNB6
  • RNB6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.95
kinase perturbation
0.93
tissue sample
0.75
transcription factor perturbation
0.74
PubMedID
0.66


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.22   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 152   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.22   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 152   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
white matter hyperintensity measurement
4
3
3
6.7
72.6
1
1
1
15.8
caudate nucleus volume
1
1
0
5.8
2.7
disease progression measurement
1
1
0
13.4
0.7
metastasis measurement
1
1
0
13.4
0.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
white matter hyperintensity measurement
3
6.7
72.6
1
15.8
caudate nucleus volume
0
5.8
2.7
disease progression measurement
0
13.4
0.7
metastasis measurement
0
13.4
0.7
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Enah/Vasp-like
746207
Macaque
Enah/Vasp-like
706316
Mouse
MGI:1194884
14026
Rat
RGD:621150
79115
Dog
Enah/Vasp-like
VGNC:40505
480433
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Enah/Vasp-like
Macaque
Enah/Vasp-like
Mouse
Rat
Dog
Enah/Vasp-like
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9UI08-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (13)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
Generation of second messenger molecules
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Axon guidance
Developmental Biology
Generation of second messenger molecules
Immune System
Gene Ontology Terms (22)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (71)
1 – 10 of 71
VASP
Tbio
Novelty:  0.00041984
p_int:  1
Score:  0.999
Data Source:  BioPlex,STRINGDB
TRMT61A
Tbio
Family:  Enzyme
Novelty:  0.04443394
p_int:  0.999999879
p_ni:  1.13e-7
p_wrong:  8e-9
Score:  0.263
Data Source:  BioPlex,STRINGDB
ENAH
Tbio
Novelty:  0.02329247
p_int:  0.999964564
p_ni:  0.000035436
Score:  0.999
Data Source:  BioPlex,STRINGDB
UBP1
Tbio
Family:  TF
Novelty:  0.01140885
p_int:  0.999385589
p_ni:  0.000614407
p_wrong:  4e-9
Score:  0.169
Data Source:  BioPlex,STRINGDB
DDX49
Tbio
Family:  Enzyme
Novelty:  0.14100169
p_int:  0.999165077
p_ni:  0.000059193
p_wrong:  0.00077573
Score:  0.197
Data Source:  BioPlex,STRINGDB
ENDOG
Tbio
Family:  Enzyme
Novelty:  0.00404275
p_int:  0.9987966
p_ni:  0.001203372
p_wrong:  2.8e-8
Data Source:  BioPlex
TACC3
Tbio
Novelty:  0.00708723
p_int:  0.996634781
p_ni:  0.003096769
p_wrong:  0.000268449
Score:  0.156
Data Source:  BioPlex,STRINGDB
EXD2
Tbio
Family:  Enzyme
Novelty:  0.09804411
p_int:  0.989285612
p_ni:  0.010714388
Score:  0.163
Data Source:  BioPlex,STRINGDB
LETMD1
Tbio
Novelty:  0.02790517
p_int:  0.985953688
p_ni:  0.002052077
p_wrong:  0.011994235
Score:  0.183
Data Source:  BioPlex,STRINGDB
NECTIN4
Tclin
Novelty:  0.00694563
p_int:  0.982908282
p_ni:  0.017091718
Score:  0.237
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  35.22

PubMed score by year
PubTator Score  36.97

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: