Tbio FEZ2 Fasciculation and elongation protein zeta-2

Protein Summary

Description

Involved in axonal outgrowth and fasciculation. This gene is an ortholog of the C. elegans unc-76 gene, which is necessary for normal axonal bundling and elongation within axon bundles. Other orthologs include the rat gene that encodes zygin II, which can bind to synaptotagmin. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9UHY8
• Q5EBN3
• Q76LN0
• Q99690

Gene Name

• FEZ2

Ensembl ID

• ENST00000379245
• ENSP00000368547
• ENSG00000171055
• ENST00000405912
• ENSP00000385112

Symbol

• HUM3CL

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
kinase perturbation	0.98
transcription factor perturbation	0.97
virus perturbation	0.92
tissue sample	0.69

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.83   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 164   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.83   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 164   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0