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Tbio
ENOPH1
Enolase-phosphatase E1

Protein Summary
Description
Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000273920
  • ENSP00000273920
  • ENSG00000145293
  • ENST00000505846
  • ENSP00000427209

Symbol
  • MASA
  • E1
  • MASA
  • mtnC
  • MST145
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.88
transcription factor binding site profile
0.81
transcription factor
0.79
transcription factor perturbation
0.74
tissue sample
0.66


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.48   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 142   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.48   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 142   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
1
1
0
1
61
BMI-adjusted waist circumference
1
1
1
46.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
0
1
61
BMI-adjusted waist circumference
1
46.9
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
enolase-phosphatase 1
VGNC:2998
461214
Mouse
MGI:1915120
67870
Rat
RGD:1309016
305177
Dog
enolase-phosphatase 1
VGNC:40369
478452
Horse
enolase-phosphatase 1
VGNC:17586
100060891
Species
Name
OMA
EggNOG
Inparanoid
Chimp
enolase-phosphatase 1
Mouse
Rat
Dog
enolase-phosphatase 1
Horse
enolase-phosphatase 1
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9UHY7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (10)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Reactome
Methionine salvage pathway
Reactome
Sulfur amino acid metabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of amino acids and derivatives
Methionine salvage pathway
Sulfur amino acid metabolism
Gene Ontology Terms (8)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-UniRule
Inferred from Electronic Annotation (IEA)
UniProtKB-UniRule
Inferred from Electronic Annotation (IEA)
UniProtKB-UniRule
Protein-Protein Interactions (73)
1 – 10 of 73
RNF41
Tbio
Family:  Enzyme
Novelty:  0.01953473
p_int:  0.999980051
p_ni:  0.000019948
p_wrong:  1e-9
Score:  0.366
Data Source:  BioPlex,STRINGDB
CARD9
Tbio
Family:  Enzyme
Novelty:  0.00547101
p_int:  0.999906185
p_ni:  0.000093814
p_wrong:  1e-9
Score:  0.825
Data Source:  BioPlex,STRINGDB
THEM4
Tbio
Family:  Enzyme
Novelty:  0.0191855
p_int:  0.999215802
p_ni:  0.000784198
Score:  0.679
Data Source:  BioPlex,STRINGDB
VPS52
Tbio
Novelty:  0.01439614
p_int:  0.997358269
p_ni:  0.002641731
Score:  0.244
Data Source:  BioPlex,STRINGDB
APIP
Tbio
Family:  Enzyme
Novelty:  0.04661109
Score:  0.997
Data Source:  STRINGDB
ADI1
Tbio
Family:  Enzyme
Novelty:  0.00908955
Score:  0.996
Data Source:  STRINGDB
SMS
Tchem
Family:  Enzyme
Novelty:  0.02447112
Score:  0.955
Data Source:  STRINGDB
MRI1
Tbio
Family:  Enzyme
Novelty:  0.01167103
Score:  0.921
Data Source:  STRINGDB
PGM3
Tbio
Family:  Enzyme
Novelty:  0.00515842
Score:  0.874
Data Source:  STRINGDB
EEF1B2
Tbio
Novelty:  0.00970356
Score:  0.869
Data Source:  STRINGDB
Publication Statistics
PubMed Score  14.48

PubMed score by year
PubTator Score  14.88

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer