Tbio ADGRE2 Adhesion G protein-coupled receptor E2

Protein Summary

Description

Cell surface receptor that binds to the chondroitin sulfate moiety of glycosaminoglycan chains and promotes cell attachment. Promotes granulocyte chemotaxis, degranulation and adhesion. In macrophages, promotes the release of inflammatory cytokines, including IL8 and TNF. Signals probably through G-proteins. Is a regulator of mast cell degranulation (PubMed:26841242). This gene encodes a member of the class B seven-span transmembrane (TM7) subfamily of G-protein coupled receptors. These proteins are characterized by an extended extracellular region with a variable number of N-terminal epidermal growth factor-like domains coupled to a TM7 domain via a mucin-like spacer domain. The encoded protein is expressed mainly in myeloid cells where it promotes cell-cell adhesion through interaction with chondroitin sulfate chains. This gene is situated in a cluster of related genes on chromosome 19. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]

Uniprot Accession IDs

• Q9UHX3
• B4DQ96
• E7ESD7
• E9PBR1
• E9PEL6
• E9PFQ5
• E9PG91
• Q8NG96
• Q9Y4B1

Gene Name

• ADGRE2

Ensembl ID

• ENST00000315576
• ENSP00000319883
• ENSG00000127507
• ENST00000392965
• ENSP00000376692
• ENST00000594076
• ENSP00000472735
• ENST00000594294
• ENSP00000470725
• ENST00000595839
• ENSP00000469277
• ENST00000596991
• ENSP00000472280

Symbol

• EMR2
• VBU
• CD97
• EMR2
• CD312

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
tissue sample	0.65
molecular function	0.6
microRNA	0.49
PubMedID	0.45

Protein Classes

PANTHER Classes

Protein / Receptor / G-protein Coupled Receptor / Adhesion G Protein-coupled Receptor E2

Protein / Defense/immunity Protein / Antibacterial Response Protein / Adhesion G Protein-coupled Receptor E2

Protein / ... / Protease / Adhesion G Protein-coupled Receptor E2

DTO Classes

Protein / G-protein Coupled Receptor / Adhesion Class / Adhesion G Protein-coupled Receptor E2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.5   (req: < 5)

Gene RIFs: 24   (req: <= 3)

Antibodies: 436   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.5   (req: >= 5)

Gene RIFs: 24   (req: > 3)

Antibodies: 436   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0