You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
ADGRE2
Adhesion G protein-coupled receptor E2

Protein Summary
Description
Cell surface receptor that binds to the chondroitin sulfate moiety of glycosaminoglycan chains and promotes cell attachment. Promotes granulocyte chemotaxis, degranulation and adhesion. In macrophages, promotes the release of inflammatory cytokines, including IL8 and TNF. Signals probably through G-proteins. Is a regulator of mast cell degranulation (PubMed:26841242). This gene encodes a member of the class B seven-span transmembrane (TM7) subfamily of G-protein coupled receptors. These proteins are characterized by an extended extracellular region with a variable number of N-terminal epidermal growth factor-like domains coupled to a TM7 domain via a mucin-like spacer domain. The encoded protein is expressed mainly in myeloid cells where it promotes cell-cell adhesion through interaction with chondroitin sulfate chains. This gene is situated in a cluster of related genes on chromosome 19. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this g ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000315576
  • ENSP00000319883
  • ENSG00000127507
  • ENST00000392965
  • ENSP00000376692
  • ENST00000594076
  • ENSP00000472735
  • ENST00000594294
  • ENSP00000470725
  • ENST00000595839
  • ENSP00000469277
  • ENST00000596991
  • ENSP00000472280

Symbol
  • EMR2
  • VBU
  • CD97
  • EMR2
  • CD312
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
tissue sample
0.65
molecular function
0.6
microRNA
0.49
PubMedID
0.45


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.79   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 436   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.79   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 436   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (14)
1 – 10 of 14
ADGRE5
Tbio
Family:  GPCR
Novelty:  0.01137558
p_int:  0.999995548
p_wrong:  0.000004452
Score:  0.238
Data Source:  BioPlex,STRINGDB
CD55
Tbio
Novelty:  0.0005689
Score:  0.789
Data Source:  STRINGDB
FSD1L
Tdark
Novelty:  0.54371192
Score:  0.755
Data Source:  STRINGDB
FSD1
Tbio
Novelty:  0.03452477
Score:  0.754
Data Source:  STRINGDB
MLN
Tbio
Novelty:  0.0010297
Score:  0.618
Data Source:  STRINGDB
MUC5AC
Tbio
Novelty:  0.00074159
Score:  0.604
Data Source:  STRINGDB
JAM3
Tbio
Novelty:  0.01028735
Score:  0.532
Data Source:  STRINGDB
F11R
Tbio
Novelty:  0.00182817
Score:  0.53
Data Source:  STRINGDB
RFX1
Tbio
Family:  TF
Novelty:  0.00225236
Score:  0.529
Data Source:  STRINGDB
PILRA
Tbio
Novelty:  0.05154386
Score:  0.466
Data Source:  STRINGDB
Pathways (10)
Class B/2 (Secretin family receptors) (R-HSA-373080)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class B/2 (Secretin family receptors)
Reactome
GPCR ligand binding
Reactome
Signal Transduction
Reactome
Signaling by GPCR
Name
Explore in Pharos
Explore in Source
Class B/2 (Secretin family receptors)
GPCR ligand binding
Signal Transduction
Signaling by GPCR
Gene Ontology Terms (16)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
adhesion G protein-coupled receptor E2
VGNC:6606
455788
Dog
adhesion G protein-coupled receptor E2
610750
Horse
adhesion G protein-coupled receptor E2
100064454
Pig
adhesion G protein-coupled receptor E2-like
100516957
Anole lizard
adhesion G protein-coupled receptor E5
100554282
Species
Name
OMA
EggNOG
Inparanoid
Chimp
adhesion G protein-coupled receptor E2
Dog
adhesion G protein-coupled receptor E2
Horse
adhesion G protein-coupled receptor E2
Pig
adhesion G protein-coupled receptor E2-like
Anole lizard
adhesion G protein-coupled receptor E5
Publication Statistics
PubMed Score 45.79
PubMed score by year
PubTator Score 33.97
PubTator score by year
Patents
Patents by year