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Tbio
ADGRE2
Adhesion G protein-coupled receptor E2

Protein Summary
Description
Cell surface receptor that binds to the chondroitin sulfate moiety of glycosaminoglycan chains and promotes cell attachment. Promotes granulocyte chemotaxis, degranulation and adhesion. In macrophages, promotes the release of inflammatory cytokines, including IL8 and TNF. Signals probably through G-proteins. Is a regulator of mast cell degranulation (PubMed:26841242). This gene encodes a member of the class B seven-span transmembrane (TM7) subfamily of G-protein coupled receptors. These proteins are characterized by an extended extracellular region with a variable number of N-terminal epidermal growth factor-like domains coupled to a TM7 domain via a mucin-like spacer domain. The encoded protein is expressed mainly in myeloid cells where it promotes cell-cell adhesion through interaction with chondroitin sulfate chains. This gene is situated in a cluster of related genes on chromosome 19. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this g ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000315576
  • ENSP00000319883
  • ENSG00000127507
  • ENST00000392965
  • ENSP00000376692
  • ENST00000594076
  • ENSP00000472735
  • ENST00000594294
  • ENSP00000470725
  • ENST00000595839
  • ENSP00000469277
  • ENST00000596991
  • ENSP00000472280

Symbol
  • EMR2
  • VBU
  • CD97
  • EMR2
  • CD312
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
tissue sample
0.65
molecular function
0.6
microRNA
0.49
PubMedID
0.45


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.89   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 436   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.89   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 436   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (10)
Class B/2 (Secretin family receptors) (R-HSA-373080)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class B/2 (Secretin family receptors)
Reactome
GPCR ligand binding
Reactome
Signal Transduction
Reactome
Signaling by GPCR
Name
Explore in Pharos
Explore in Source
Class B/2 (Secretin family receptors)
GPCR ligand binding
Signal Transduction
Signaling by GPCR
Protein-Protein Interactions (14)
1 – 10 of 14
ADGRE5
Tbio
Family: GPCR
Novelty: 0.01324684
p_int: 0.999995548
p_wrong: 0.000004452
Score: 0.238
Data Source: BioPlex,STRINGDB
CD55
Tbio
Novelty: 0.00064328
Score: 0.789
Data Source: STRINGDB
FSD1L
Tdark
Novelty: 0.58823529
Score: 0.755
Data Source: STRINGDB
FSD1
Tbio
Novelty: 0.043447
Score: 0.754
Data Source: STRINGDB
MLN
Tbio
Novelty: 0.00089433
Score: 0.618
Data Source: STRINGDB
MUC5AC
Tbio
Novelty: 0.00053768
Score: 0.604
Data Source: STRINGDB
JAM3
Tbio
Novelty: 0.012066
Score: 0.532
Data Source: STRINGDB
F11R
Tbio
Novelty: 0.00254252
Score: 0.53
Data Source: STRINGDB
RFX1
Tbio
Family: TF
Novelty: 0.0029798
Score: 0.529
Data Source: STRINGDB
PILRA
Tbio
Novelty: 0.07858669
Score: 0.466
Data Source: STRINGDB
Publication Statistics
PubMed Score  53.89

PubMed score by year
PubTator Score  33.97

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer