Tbio SLC12A6 Solute carrier family 12 member 6

Protein Summary

Description

Mediates electroneutral potassium-chloride cotransport. May be activated by cell swelling. May contribute to cell volume homeostasis in single cells. This gene is a member of the K-Cl cotransporter (KCC) family. K-Cl cotransporters are integral membrane proteins that lower intracellular chloride concentrations below the electrochemical equilibrium potential. The proteins encoded by this gene are activated by cell swelling induced by hypotonic conditions. Alternate splicing results in multiple transcript variants encoding different isoforms. Mutations in this gene are associated with agenesis of the corpus callosum with peripheral neuropathy. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9UHW9
• A0AV76
• Q2VI00
• Q7Z2E7
• Q7Z4G5
• Q8TDD4
• Q9UFR2
• Q9Y642
• Q9Y665

Gene Name

• SLC12A6

Ensembl ID

• ENST00000290209
• ENSP00000290209
• ENSG00000140199
• ENST00000354181
• ENSP00000346112
• ENST00000397702
• ENSP00000380814
• ENST00000397707
• ENSP00000380819
• ENST00000458406
• ENSP00000387725
• ENST00000558589
• ENSP00000452776
• ENST00000558667
• ENSP00000453473
• ENST00000560611
• ENSP00000454168

Symbol

• KCC3
• KCC3
• ACCPN
• KCC3A
• KCC3B

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.76
protein domain	0.73
tissue sample	0.72
kinase perturbation	0.71
transcription factor	0.71

Protein Classes

DTO Classes

Protein / Transporter / Slc Superfamily Of Solute Carriers / Slc12 Family Of Cation-coupled Chloride Transporters / Solute Carrier Family 12 Member 6

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 96.41   (req: < 5)

Gene RIFs: 29   (req: <= 3)

Antibodies: 199   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 96.41   (req: >= 5)

Gene RIFs: 29   (req: > 3)

Antibodies: 199   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0