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Tbio
PFDN2
Prefoldin subunit 2

Protein Summary
Description
Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. This gene encodes a member of the prefoldin beta subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368010
  • ENSP00000356989
  • ENSG00000143256

Symbol
  • PFD2
  • PFD2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.98
kinase perturbation
0.96
histone modification site profile
0.84
virus perturbation
0.79
transcription factor binding site profile
0.78


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.95   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 156   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.95   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 156   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (182)
PFDN4
Tbio
Novelty:  0.02133605
p_int:  0.999995941
p_ni:  0.000004059
Score:  0.999
Data Source:  BioPlex,STRINGDB
VBP1
Tbio
Novelty:  0.0428293
p_int:  0.999980947
p_ni:  0.000019053
Score:  0.999
Data Source:  BioPlex,STRINGDB
DCAF12
Tbio
Novelty:  0.15472702
p_int:  0.999944428
p_ni:  0.000055572
Data Source:  BioPlex
PFDN5
Tbio
Novelty:  0.07673574
p_int:  0.999801116
p_ni:  0.000198884
Score:  0.999
Data Source:  BioPlex,STRINGDB
DTL
Tbio
Novelty:  0.01659105
p_int:  0.999785121
p_ni:  0.000214879
Data Source:  BioPlex
DCAF4
Tbio
Novelty:  0.24190895
p_int:  0.99968755
p_ni:  0.00031245
Data Source:  BioPlex
UXT
Tbio
Novelty:  0.0272609
p_int:  0.999637261
p_ni:  0.000362739
Score:  0.912
Data Source:  BioPlex,STRINGDB
DDB2
Tbio
Novelty:  0.00648809
p_int:  0.998404973
p_ni:  0.001595027
Score:  0.419
Data Source:  BioPlex,STRINGDB
PFDN1
Tbio
Novelty:  0.08811378
p_int:  0.998396189
p_ni:  0.001603811
Score:  0.999
Data Source:  BioPlex,STRINGDB
CDK17
Tchem
Family:  Kinase
Novelty:  0.25046297
p_int:  0.9973688
p_ni:  0.0026312
Score:  0.158
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Chaperonin-mediated protein folding (R-HSA-390466)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chaperonin-mediated protein folding
Reactome
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding
Reactome
Metabolism of proteins
Reactome
Prefoldin mediated transfer of substrate to CCT/TriC
Reactome
Protein folding
Name
Explore in Pharos
Explore in Source
Chaperonin-mediated protein folding
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding
Metabolism of proteins
Prefoldin mediated transfer of substrate to CCT/TriC
Protein folding
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
2
2
3
85.2
serum non-albumin protein measurement
1
2
2
84.7
4
2
0
1.1
82.8
leukocyte count
2
2
2
81.1
childhood onset asthma
1
1
0
1.1
80.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
3
85.2
serum non-albumin protein measurement
2
84.7
0
1.1
82.8
leukocyte count
2
81.1
childhood onset asthma
0
1.1
80.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
prefoldin subunit 2
VGNC:1448
457446
Mouse
MGI:1276111
18637
Rat
RGD:1591406
685607
Dog
prefoldin subunit 2
VGNC:44440
488648
Horse
prefoldin subunit 2
VGNC:21333
100066280
Species
Name
OMA
EggNOG
Inparanoid
Chimp
prefoldin subunit 2
Mouse
Rat
Dog
prefoldin subunit 2
Horse
prefoldin subunit 2
Publication Statistics
PubMed Score 11.95
PubMed score by year
PubTator Score 6.55
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title