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Tbio
SERTAD1
SERTA domain-containing protein 1

Protein Summary
Description
Acts at E2F-responsive promoters as coregulator to integrate signals provided by PHD- and/or bromodomain-containing transcription factors. Stimulates E2F1/TFDP1 transcriptional activity. Renders the activity of cyclin D1/CDK4 resistant to the inhibitory effects of CDKN2A/p16INK4A.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000357949
  • ENSP00000350633
  • ENSG00000197019

Symbol
  • SEI1
  • TRIPBR1
  • SEI1
  • TRIPBR1
  • TRIP-Br1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
viral protein
1
virus
1
transcription factor binding site profile
0.89
cell type or tissue
0.65
transcription factor
0.61


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.33   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 176   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.33   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 176   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
2
1
2
71.6
reticulocyte measurement
3
1
3
69.3
mean reticulocyte volume
1
2
2
63
monocyte percentage of leukocytes
1
1
1
32.7
1
1
0
1.8
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
2
71.6
reticulocyte measurement
3
69.3
mean reticulocyte volume
2
63
monocyte percentage of leukocytes
1
32.7
0
1.8
17.8
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SERTA domain containing 1
VGNC:12098
456037
Macaque
SERTA domain containing 1
701562
Mouse
MGI:1913438
55942
Rat
RGD:1549778
361526
Dog
SERTA domain containing 1
VGNC:46044
484500
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SERTA domain containing 1
Macaque
SERTA domain containing 1
Mouse
Rat
Dog
SERTA domain containing 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9UHV2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (5)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (27)
1 – 10 of 27
CDCA4
Tbio
Novelty:  0.04549061
Score:  0.804
Data Source:  STRINGDB
RPA2
Tbio
Novelty:  0.00879115
Score:  0.8
Data Source:  STRINGDB
CCNA2
Tchem
Novelty:  0.00049887
Score:  0.766
Data Source:  STRINGDB
STN1
Tbio
Novelty:  0.01309587
Score:  0.757
Data Source:  STRINGDB
EMID1
Tbio
Novelty:  0.14161673
Score:  0.539
Data Source:  STRINGDB
CDK4
Tclin
Family:  Kinase
Novelty:  0.00036742
Score:  0.537
Data Source:  STRINGDB
RMND5A
Tbio
Novelty:  0.01820349
Score:  0.529
Data Source:  STRINGDB
MRPL45
Tdark
Novelty:  0.42464896
Score:  0.525
Data Source:  STRINGDB
CREBBP
Tchem
Family:  Epigenetic
Novelty:  0.00111166
Score:  0.518
Data Source:  STRINGDB
CDKN2A
Tbio
Novelty:  0.00014147
Score:  0.489
Data Source:  STRINGDB
Publication Statistics
PubMed Score  28.33

PubMed score by year
PubTator Score  19.73

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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