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Tbio
BAIAP2L1
Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1

Protein Classes
Protein Summary
Description
May function as adapter protein. Involved in the formation of clusters of actin bundles. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. This gene encodes a member of the IMD (IRSp53/MIM homology domain) family. Members of this family can be subdivided in two groups, the IRSp53-like and MIM-like, based on the presence or absence of the SH3 (Src homology 3) domain. The protein encoded by this gene contains a conserved IMD, also known as F-actin bundling domain, at the N-terminus, and a canonical SH3 domain near the C-terminus, so it belongs to the IRSp53-like group. This protein is the substrate for insulin receptor tyrosine kinase and binds to the small GTPase Rac. It is involved in signal transduction pathways that link deformation of the plasma membrane and remodeling of the actin cytoskeleton. It also promotes actin assembly and membrane protrusions when overexpressed in mammalian cells, and is essential to the formation of a potent a ...more
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.94
kinase perturbation
0.91
ligand (protein) perturbation
0.83
transcription factor binding site profile
0.82
virus perturbation
0.72


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.74   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 177   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.74   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 177   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
7
4
7
98.7
testosterone measurement
5
5
5
97
urate measurement
2
2
2
80.6
lymphocyte percentage of leukocytes
1
1
1
72.6
monocyte count
1
1
1
70
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
7
98.7
testosterone measurement
5
97
urate measurement
2
80.6
lymphocyte percentage of leukocytes
1
72.6
monocyte count
1
70
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
BAI1 associated protein 2 like 1
VGNC:7349
463559
Macaque
BAI1 associated protein 2 like 1
718278
Mouse
MGI:1914148
66898
Rat
RGD:1308452
304282
Dog
BAI1 associated protein 2 like 1
VGNC:38372
479748
Species
Name
OMA
EggNOG
Inparanoid
Chimp
BAI1 associated protein 2 like 1
Macaque
BAI1 associated protein 2 like 1
Mouse
Rat
Dog
BAI1 associated protein 2 like 1
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9UHR4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Protein-Protein Interactions (38)
1 – 10 of 38
BAIAP2
Tbio
Novelty:  0.00949996
p_int:  0.999995843
p_ni:  0.000004157
Score:  0.555
Data Source:  BioPlex,STRINGDB
GPRC5C
Tbio
Family:  GPCR
Novelty:  0.16942353
p_int:  0.999984937
p_ni:  0.000015055
p_wrong:  9e-9
Score:  0.173
Data Source:  BioPlex,STRINGDB
CDKN3
Tbio
Family:  Enzyme
Novelty:  0.00093913
p_int:  0.999951337
p_ni:  0.000048663
Data Source:  BioPlex
MUM1
Tbio
Family:  Epigenetic
Novelty:  0.11597088
p_int:  0.998496153
p_ni:  0.001503752
p_wrong:  9.5e-8
Score:  0.416
Data Source:  BioPlex,STRINGDB
TMEM184A
Tbio
Novelty:  0.16408207
p_int:  0.994565105
p_ni:  0.005434828
p_wrong:  6.7e-8
Score:  0.206
Data Source:  BioPlex,STRINGDB
MARVELD2
Tbio
Novelty:  0.01228406
p_int:  0.97129349
p_ni:  0.014796904
p_wrong:  0.013909606
Score:  0.25
Data Source:  BioPlex,STRINGDB
WASL
Tbio
Novelty:  0.0029314
Score:  0.964
Data Source:  STRINGDB
EPS8
Tbio
Family:  Enzyme
Novelty:  0.01023541
Score:  0.833
Data Source:  STRINGDB
WAS
Tbio
Novelty:  0.00087362
Score:  0.785
Data Source:  STRINGDB
TP53
Tchem
Family:  TF
Novelty:  0.00001907
Score:  0.696
Data Source:  STRINGDB
Publication Statistics
PubMed Score  20.74

PubMed score by year
PubTator Score  12.22

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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