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Tbio
POLG2
DNA polymerase subunit gamma-2, mitochondrial

Protein Summary
Description
Mitochondrial polymerase processivity subunit. Stimulates the polymerase and exonuclease activities, and increases the processivity of the enzyme. Binds to ss-DNA. This gene encodes the processivity subunit of the mitochondrial DNA polymerase gamma. The encoded protein forms a heterotrimer containing one catalytic subunit and two processivity subunits. This protein enhances DNA binding and promotes processive DNA synthesis. Mutations in this gene result in autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions.[provided by RefSeq, Sep 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000539111
  • ENSP00000442563
  • ENSG00000256525

Symbol
  • MTPOLB
  • HP55
  • POLB
  • PEOA4
  • POLGB
  • MTPOLB
  • POLG-BETA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.89
virus perturbation
0.83
gene perturbation
0.79
cellular component
0.71
histone modification site profile
0.56


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.75   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 147   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.75   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 147   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
1
2
83.5
sex hormone-binding globulin measurement
1
1
1
56.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
83.5
sex hormone-binding globulin measurement
1
56.7
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
DNA polymerase gamma 2, accessory subunit
717856
Mouse
MGI:1354947
50776
Rat
RGD:1305128
303612
Dog
DNA polymerase gamma 2, accessory subunit
VGNC:44782
490910
Horse
DNA polymerase gamma 2, accessory subunit
VGNC:21660
100064219
Species
Name
OMA
EggNOG
Inparanoid
Macaque
DNA polymerase gamma 2, accessory subunit
Mouse
Rat
Dog
DNA polymerase gamma 2, accessory subunit
Horse
DNA polymerase gamma 2, accessory subunit
Protein Structure (8 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9UHN1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 8
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (3)
Mitochondrial biogenesis (R-HSA-1592230)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Mitochondrial biogenesis
Reactome
Organelle biogenesis and maintenance
Reactome
Transcriptional activation of mitochondrial biogenesis
Name
Explore in Pharos
Explore in Source
Mitochondrial biogenesis
Organelle biogenesis and maintenance
Transcriptional activation of mitochondrial biogenesis
Gene Ontology Terms (16)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (115)
1 – 10 of 115
POLG
Tchem
Family: Enzyme
Novelty: 0.00172189
p_int: 0.999999992
p_ni: 8e-9
Score: 0.983
Data Source: BioPlex,STRINGDB
ALDH6A1
Tbio
Family: Enzyme
Novelty: 0.03785268
p_int: 0.999960294
p_ni: 0.000039706
Score: 0.225
Data Source: BioPlex,STRINGDB
ADNP
Tbio
Family: TF
Novelty: 0.00785336
p_int: 0.998361656
p_ni: 0.001638344
Score: 0.23
Data Source: BioPlex,STRINGDB
IFIT2
Tbio
Novelty: 0.01023074
p_int: 0.99225022
p_ni: 0.00774978
Score: 0.823
Data Source: BioPlex,STRINGDB
HOMER3
Tbio
Novelty: 0.04408998
p_int: 0.980930787
p_ni: 0.019069199
p_wrong: 1.4e-8
Score: 0.524
Data Source: BioPlex,STRINGDB
GLDC
Tbio
Family: Enzyme
Novelty: 0.00900467
p_int: 0.94291368
p_ni: 0.05708632
Score: 0.214
Data Source: BioPlex,STRINGDB
SEC22C
Tdark
Novelty: 0.53697928
p_int: 0.910497764
p_ni: 0.089502233
p_wrong: 3e-9
Score: 0.455
Data Source: BioPlex,STRINGDB
EPRS
Tchem
Family: Enzyme
Novelty: 0.00084896
Score: 0.989
Data Source: STRINGDB
TWNK
Tbio
Novelty: 0.00393371
Score: 0.936
Data Source: STRINGDB
GABPA
Tbio
Family: TF
Novelty: 0.01731451
Score: 0.904
Data Source: STRINGDB
Publication Statistics
PubMed Score  39.75

PubMed score by year
PubTator Score  44.97

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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