Tbio OPN4 Melanopsin

Protein Summary

Description

Photoreceptor required for regulation of circadian rhythm. Contributes to pupillar reflex and other non-image forming responses to light. May be able to isomerize covalently bound all-trans retinal back to 11-cis retinal (By similarity). Opsins are members of the guanine nucleotide-binding protein (G protein)-coupled receptor superfamily. This gene encodes a photoreceptive opsin protein that is expressed within the ganglion and amacrine cell layers of the retina. In mouse, retinal ganglion cell axons expressing this gene projected to the suprachiasmatic nucleus and other brain nuclei involved in circadian photoentrainment. In mouse, this protein is coupled to a transient receptor potential (TRP) ion channel through a G protein signaling pathway and produces a physiologic light response via membrane depolarization and increased intracellular calcium. The protein functions as a sensory photopigment and may also have photoisomerase activity. Experiments with knockout mice indicate that this gene attenuates, but does not abolish, photoentrainment. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9UHM6
• B7ZLB3
• Q14D01
• Q2PP22
• Q8NGQ9

Gene Name

• OPN4

Ensembl ID

• ENST00000241891
• ENSP00000241891
• ENSG00000122375
• ENST00000372071
• ENSP00000361141

Symbol

• MOP
• MOP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.6
protein domain	0.58
transcription factor	0.57
cell line	0.53
tissue	0.52

Protein Classes

PANTHER Classes

Protein / Receptor / G-protein Coupled Receptor / Melanopsin

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Melanopsin

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1287.78   (req: < 5)

Gene RIFs: 35   (req: <= 3)

Antibodies: 78   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1287.78   (req: >= 5)

Gene RIFs: 35   (req: > 3)

Antibodies: 78   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0