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Tbio
OPN4
Melanopsin

Protein Summary
Description
Photoreceptor required for regulation of circadian rhythm. Contributes to pupillar reflex and other non-image forming responses to light. May be able to isomerize covalently bound all-trans retinal back to 11-cis retinal (By similarity). Opsins are members of the guanine nucleotide-binding protein (G protein)-coupled receptor superfamily. This gene encodes a photoreceptive opsin protein that is expressed within the ganglion and amacrine cell layers of the retina. In mouse, retinal ganglion cell axons expressing this gene projected to the suprachiasmatic nucleus and other brain nuclei involved in circadian photoentrainment. In mouse, this protein is coupled to a transient receptor potential (TRP) ion channel through a G protein signaling pathway and produces a physiologic light response via membrane depolarization and increased intracellular calcium. The protein functions as a sensory photopigment and may also have photoisomerase activity. Experiments with knockout mice indicate that th ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000241891
  • ENSP00000241891
  • ENSG00000122375
  • ENST00000372071
  • ENSP00000361141

Symbol
  • MOP
  • MOP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.6
protein domain
0.58
transcription factor
0.57
cell line
0.53
tissue
0.52


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1066.36   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 78   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1066.36   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 78   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (246)
STX12
Tbio
Novelty:  0.03836262
p_int:  0.920015937
p_ni:  0.079984057
p_wrong:  6e-9
Score:  0.367
Data Source:  BioPlex,STRINGDB
NDFIP1
Tbio
Novelty:  0.04496467
p_int:  0.876943874
p_ni:  0.123056126
Score:  0.242
Data Source:  BioPlex,STRINGDB
STX10
Tbio
Novelty:  0.05193552
p_int:  0.764082392
p_ni:  0.234927769
p_wrong:  0.000989839
Score:  0.827
Data Source:  BioPlex,STRINGDB
GRK2
Tchem
Family:  Kinase
Novelty:  0.00200696
Score:  0.968
Data Source:  STRINGDB
HCRT
Tbio
Novelty:  0.00034048
Score:  0.947
Data Source:  STRINGDB
GNAQ
Tbio
Novelty:  0.0008997
Score:  0.945
Data Source:  STRINGDB
GNA11
Tchem
Novelty:  0.00128664
Score:  0.942
Data Source:  STRINGDB
PLCB4
Tbio
Family:  Enzyme
Novelty:  0.01840915
Score:  0.937
Data Source:  STRINGDB
PROK2
Tbio
Novelty:  0.00512397
Score:  0.935
Data Source:  STRINGDB
NPS
Tbio
Novelty:  0.00692108
Score:  0.933
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (9)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Opsins
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (q) signalling events
GPCR downstream signalling
GPCR ligand binding
Opsins
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
1
1
33.1
electrocardiography
1
1
2
15.8
apolipoprotein A 1 measurement
1
1
1
6.1
high density lipoprotein cholesterol measurement
1
1
1
1.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
33.1
electrocardiography
2
15.8
apolipoprotein A 1 measurement
1
6.1
high density lipoprotein cholesterol measurement
1
1.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
opsin 4
VGNC:14323
107966782
Macaque
opsin 4
699800
Mouse
MGI:1353425
30044
Rat
RGD:621701
192223
Dog
opsin 4
VGNC:51909
611027
Species
Name
OMA
EggNOG
Inparanoid
Chimp
opsin 4
Macaque
opsin 4
Mouse
Rat
Dog
opsin 4
Publication Statistics
PubMed Score 1066.36
PubMed score by year
PubTator Score 351.67
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title