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Tchem
DPP7
Dipeptidyl peptidase 2

Protein Summary
Description
Plays an important role in the degradation of some oligopeptides. The protein encoded by this gene is a post-proline cleaving aminopeptidase expressed in quiescent lymphocytes. The resting lymphocytes are maintained through suppression of apoptosis, a state which is disrupted by inhibition of this novel serine protease. The enzyme has strong sequence homology with prolylcarboxypeptidase and is active at both acidic and neutral pH. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371579
  • ENSP00000360635
  • ENSG00000176978

Symbol
  • DPP2
  • QPP
  • QPP
  • DPP2
  • DPPII
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.91
cell type or tissue
0.8
histone modification site profile
0.79
disease perturbation
0.74
cellular component
0.69


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 152.89   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 259   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 152.89   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 259   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 236
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (236)
1 – 10 of 236
talabostat
Rendered image for talabostat
CHEMBL210805
Rendered image for CHEMBL210805
Boronic acid derivative
Rendered image for Boronic acid derivative
CHEMBL237336,CHEMBL189881
Rendered image for CHEMBL237336,CHEMBL189881
CHEMBL195189
Rendered image for CHEMBL195189
CHEMBL481669
Rendered image for CHEMBL481669
CHEMBL1243184
Rendered image for CHEMBL1243184
CHEMBL237119,CHEMBL191067
Rendered image for CHEMBL237119,CHEMBL191067
CHEMBL2418626
Rendered image for CHEMBL2418626
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
3
4
91.5
monocyte percentage of leukocytes
2
2
2
88
reticulocyte measurement
3
1
3
82.3
reticulocyte count
6
1
6
80.4
leukocyte count
2
2
3
70.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
4
91.5
monocyte percentage of leukocytes
2
88
reticulocyte measurement
3
82.3
reticulocyte count
6
80.4
leukocyte count
3
70.2
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
dipeptidyl peptidase 7
VGNC:13872
473101
Mouse
MGI:1933213
83768
Rat
RGD:71073
83799
Dog
dipeptidyl peptidase 7
VGNC:40076
607003
Horse
dipeptidyl peptidase 7
VGNC:17296
100059924
Species
Name
OMA
EggNOG
Inparanoid
Chimp
dipeptidyl peptidase 7
Mouse
Rat
Dog
dipeptidyl peptidase 7
Horse
dipeptidyl peptidase 7
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9UHL4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (3)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Neutrophil degranulation
Gene Ontology Terms (11)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (117)
1 – 10 of 117
CTSC
Tchem
Family:  Enzyme
Novelty:  0.00119917
Score:  0.963
Data Source:  STRINGDB
CTSA
Tchem
Family:  Enzyme
Novelty:  0.00170931
Score:  0.949
Data Source:  STRINGDB
GLB1
Tchem
Family:  Enzyme
Novelty:  0.00241713
Score:  0.926
Data Source:  STRINGDB
GUSB
Tchem
Family:  Enzyme
Novelty:  0.00053974
Score:  0.925
Data Source:  STRINGDB
GRN
Tbio
Novelty:  0.00096395
Score:  0.921
Data Source:  STRINGDB
CTSG
Tchem
Family:  Enzyme
Novelty:  0.00102052
Score:  0.919
Data Source:  STRINGDB
PYGB
Tchem
Family:  Enzyme
Novelty:  0.00224148
Score:  0.918
Data Source:  STRINGDB
NPC2
Tbio
Novelty:  0.00342898
Score:  0.916
Data Source:  STRINGDB
ARSA
Tbio
Family:  Enzyme
Novelty:  0.00469851
Score:  0.913
Data Source:  STRINGDB
FRK
Tchem
Family:  Kinase
Novelty:  0.00715757
Score:  0.913
Data Source:  STRINGDB
Publication Statistics
PubMed Score  152.89

PubMed score by year
PubTator Score  102.02

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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