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Tchem
ADAMTS1
A disintegrin and metalloproteinase with thrombospondin motifs 1

Protein Classes
Protein Summary
Description
Cleaves aggrecan, a cartilage proteoglycan, at the '1938-Glu-|-Leu-1939' site (within the chondroitin sulfate attachment domain), and may be involved in its turnover (By similarity). Has angiogenic inhibitor activity. Active metalloprotease, which may be associated with various inflammatory processes as well as development of cancer cachexia. May play a critical role in follicular rupture. This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene contains two disintegrin loops and three C-terminal TS motifs and has anti-angiogenic activity. The expression of this gene may be associated wi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000284984
  • ENSP00000284984
  • ENSG00000154734

Symbol
  • KIAA1346
  • METH1
  • C3-C5
  • METH1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.98
protein domain
0.97
gene perturbation
0.92
small molecule perturbation
0.85
transcription factor perturbation
0.84


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 220.49   (req: < 5)
Gene RIFs: 77   (req: <= 3)
Antibodies: 369   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 220.49   (req: >= 5)
Gene RIFs: 77   (req: > 3)
Antibodies: 369   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
1
1
1
21.5
neurofilament light chain measurement
1
1
1
1
late-onset Alzheimers disease
1
1
0
1.1
0.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
1
21.5
neurofilament light chain measurement
1
1
late-onset Alzheimers disease
0
1.1
0.4
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ADAM metallopeptidase with thrombospondin type 1 motif 1
VGNC:3742
473934
Macaque
ADAM metallopeptidase with thrombospondin type 1 motif 1
707778
Mouse
MGI:109249
11504
Rat
RGD:621241
79252
Dog
ADAM metallopeptidase with thrombospondin type 1 motif 1
VGNC:37590
100686153
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ADAM metallopeptidase with thrombospondin type 1 motif 1
Macaque
ADAM metallopeptidase with thrombospondin type 1 motif 1
Mouse
Rat
Dog
ADAM metallopeptidase with thrombospondin type 1 motif 1
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9UHI8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (12)
Defective B3GALTL causes Peters-plus syndrome (PpS) (R-HSA-5083635)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Defective B3GALTL causes Peters-plus syndrome (PpS)
Reactome
Degradation of the extracellular matrix
Reactome
Disease
Reactome
Diseases associated with O-glycosylation of proteins
Reactome
Diseases of glycosylation
Name
Explore in Pharos
Explore in Source
Defective B3GALTL causes Peters-plus syndrome (PpS)
Degradation of the extracellular matrix
Disease
Diseases associated with O-glycosylation of proteins
Diseases of glycosylation
Gene Ontology Terms (14)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (99)
1 – 10 of 99
IGFBP1
Tchem
Novelty:  0.0006975
p_int:  0.994809707
p_ni:  0.005190293
Score:  0.264
Data Source:  BioPlex,STRINGDB
DKK3
Tbio
Novelty:  0.00519275
p_int:  0.983350426
p_ni:  0.016649574
Score:  0.273
Data Source:  BioPlex,STRINGDB
ADAM32
Tdark
Family:  Enzyme
Novelty:  0.36071191
p_int:  0.944434909
p_ni:  0.055565091
Score:  0.217
Data Source:  BioPlex,STRINGDB
PRSS50
Tbio
Family:  Enzyme
Novelty:  0.01511883
p_int:  0.924269308
p_ni:  0.075730692
Score:  0.189
Data Source:  BioPlex,STRINGDB
PRG2
Tbio
Novelty:  0.00548995
p_int:  0.90669794
p_ni:  0.093302059
Score:  0.154
Data Source:  BioPlex,STRINGDB
PLA2G10
Tchem
Family:  Enzyme
Novelty:  0.00289317
p_int:  0.826671236
p_ni:  0.173328764
Data Source:  BioPlex
CCL3L1
Tbio
Novelty:  0.01124082
p_int:  0.815855516
p_ni:  0.184144484
Data Source:  BioPlex
IFNA21
Tbio
Novelty:  0.00581034
p_int:  0.775269279
p_ni:  0.224730721
Score:  0.183
Data Source:  BioPlex,STRINGDB
ACAN
Tbio
Novelty:  0.00033695
Score:  0.982
Data Source:  STRINGDB
THBS1
Tchem
Novelty:  0.00073905
Score:  0.932
Data Source:  STRINGDB
Publication Statistics
PubMed Score  220.49

PubMed score by year
PubTator Score  257.88

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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