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Tchem
SLC23A1
Solute carrier family 23 member 1

Protein Summary
Description
Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate. The absorption of vitamin C into the body and its distribution to organs requires two sodium-dependent vitamin C transporters. This gene encodes one of the two transporters. The encoded protein is active in bulk vitamin C transport involving epithelial surfaces. Previously, this gene had an official symbol of SLC23A2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000348729
  • ENSP00000302701
  • ENSG00000170482
  • ENST00000353963
  • ENSP00000302851

Symbol
  • SVCT1
  • YSPL3
  • SVCT1
  • YSPL3
  • SLC23A2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.98
pathway
0.78
tissue sample
0.66
gene perturbation
0.64
biological term
0.56


Related Tools
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 93.12   (req: < 5)
Gene RIFs: 36   (req: <= 3)
Antibodies: 97   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 93.12   (req: >= 5)
Gene RIFs: 36   (req: > 3)
Antibodies: 97   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
phloretin
Rendered image for phloretin
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin C measurement
1
1
1
86.9
1
1
0
1.2
72.1
viral load
1
1
1
66.8
electrocardiography
1
1
4
62.1
reticulocyte count
1
1
1
49.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin C measurement
1
86.9
0
1.2
72.1
viral load
1
66.8
electrocardiography
4
62.1
reticulocyte count
1
49.5
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 23 member 1
VGNC:8650
462104
Macaque
solute carrier family 23 member 1
693491
Mouse
MGI:1341903
20522
Rat
RGD:619875
50621
Dog
solute carrier family 23 member 1
VGNC:46282
478025
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 23 member 1
Macaque
solute carrier family 23 member 1
Mouse
Rat
Dog
solute carrier family 23 member 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9UHI7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (5)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of vitamins and cofactors
Reactome
Metabolism of water-soluble vitamins and cofactors
Reactome
Vitamin C (ascorbate) metabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of vitamins and cofactors
Metabolism of water-soluble vitamins and cofactors
Vitamin C (ascorbate) metabolism
Gene Ontology Terms (25)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (34)
1 – 10 of 34
MATR3
Tbio
Novelty:  0.01218438
Score:  0.8
Data Source:  STRINGDB
PAIP2
Tbio
Novelty:  0.04418262
Score:  0.734
Data Source:  STRINGDB
SLC33A1
Tchem
Family:  Transporter
Novelty:  0.05905408
Score:  0.689
Data Source:  STRINGDB
LCT
Tbio
Family:  Enzyme
Novelty:  0.0019382
Score:  0.671
Data Source:  STRINGDB
SIL1
Tbio
Novelty:  0.00848561
Score:  0.644
Data Source:  STRINGDB
ATP13A1
Tbio
Family:  Transporter
Novelty:  0.15331022
Score:  0.641
Data Source:  STRINGDB
SFTPB
Tbio
Novelty:  0.00163925
Score:  0.64
Data Source:  STRINGDB
PABPC4
Tbio
Novelty:  0.06854984
Score:  0.626
Data Source:  STRINGDB
FBXO42
Tbio
Novelty:  0.17658866
Score:  0.608
Data Source:  STRINGDB
SLC2A14
Tbio
Family:  Transporter
Novelty:  0.00247741
Score:  0.604
Data Source:  STRINGDB
Publication Statistics
PubMed Score  93.12

PubMed score by year
PubTator Score  56.92

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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