You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
SLC7A8
Large neutral amino acids transporter small subunit 2

Protein Summary
Description
Sodium-independent, high-affinity transport of small and large neutral amino acids such as alanine, serine, threonine, cysteine, phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc. Acts as an amino acid exchanger. Has higher affinity for L-phenylalanine than LAT1 but lower affinity for glutamine and serine. L-alanine is transported at physiological concentrations. Plays a role in basolateral (re)absorption of neutral amino acids. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. Plays an essential role in the reabsorption of neutral amino acids from the epithelial cells to the bloodstream in the kidney.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000316902
  • ENSP00000320378
  • ENSG00000092068
  • ENST00000422941
  • ENSP00000416398
  • ENST00000453702
  • ENSP00000391577
  • ENST00000529705
  • ENSP00000434345

Symbol
  • LAT2
  • LAT2
  • LPI-PC1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.9
PubMedID
0.86
molecular function
0.76
small molecule perturbation
0.7
kinase perturbation
0.66


Related Tools
RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.56   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 194   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.56   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 194   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neuroticism measurement
1
1
0
5.8
58.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neuroticism measurement
0
5.8
58.9
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 7 member 8
VGNC:12535
452793
Macaque
solute carrier family 7 member 8
713511
Mouse
MGI:1355323
50934
Rat
RGD:619904
84551
Horse
solute carrier family 7 member 8
VGNC:23273
100052453
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 7 member 8
Macaque
solute carrier family 7 member 8
Mouse
Rat
Horse
solute carrier family 7 member 8
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9UHI5-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (8)
Amino acid transport across the plasma membrane (R-HSA-352230)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amino acid transport across the plasma membrane
Reactome
Basigin interactions
Reactome
Cell surface interactions at the vascular wall
Reactome
Hemostasis
Reactome
SLC-mediated transmembrane transport
Name
Explore in Pharos
Explore in Source
Amino acid transport across the plasma membrane
Basigin interactions
Cell surface interactions at the vascular wall
Hemostasis
SLC-mediated transmembrane transport
Gene Ontology Terms (16)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (54)
1 – 10 of 54
SLC3A2
Tbio
Family: Transporter
Novelty: 0.0021506
Score: 0.988
Data Source: Reactome,STRINGDB
BSG
Tbio
Novelty: 0.0010285
Score: 0.907
Data Source: STRINGDB
SLC3A1
Tbio
Family: Transporter
Novelty: 0.003328
Score: 0.802
Data Source: STRINGDB
SLC43A1
Tbio
Family: Transporter
Novelty: 0.06939259
Score: 0.8
Data Source: STRINGDB
SLC1A7
Tchem
Family: Transporter
Novelty: 0.00067678
Score: 0.718
Data Source: STRINGDB
SLC1A5
Tchem
Family: Transporter
Novelty: 0.00201741
Score: 0.681
Data Source: STRINGDB
SLC43A2
Tbio
Family: Transporter
Novelty: 0.03620114
Score: 0.678
Data Source: STRINGDB
SLC1A4
Tbio
Family: Transporter
Novelty: 0.01334316
Score: 0.675
Data Source: STRINGDB
SLC38A2
Tbio
Family: Transporter
Novelty: 0.00808235
Score: 0.674
Data Source: STRINGDB
SLC16A10
Tbio
Family: Transporter
Novelty: 0.02363735
Score: 0.673
Data Source: STRINGDB
Publication Statistics
PubMed Score  31.56

PubMed score by year
PubTator Score  7.59

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: