Tbio IP6K2 Inositol hexakisphosphate kinase 2

Protein Summary

Description

Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4. This gene encodes a protein that belongs to the inositol phosphokinase (IPK) family. This protein is likely responsible for the conversion of inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). It may also convert 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4 and affect the growth suppressive and apoptotic activities of interferon-beta in some ovarian cancers. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9UHH9
• A8K3B1
• B4E3G6
• G8JLL6
• Q6P0N8
• Q9BSZ6
• Q9BUW3
• Q9H4P7
• Q9NT63
• Q9UFU6
• InsP6 kinase 2

Gene Name

• IP6K2

Ensembl ID

• ENST00000328631
• ENSP00000331103
• ENSG00000068745
• ENST00000340879
• ENSP00000341925
• ENST00000413298
• ENSP00000396203
• ENST00000416707
• ENSP00000387759
• ENST00000431721
• ENSP00000414139
• ENST00000432678
• ENSP00000400812
• ENST00000446860
• ENSP00000399052

Symbol

• IHPK2
• PIUS
• IHPK2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.99
virus perturbation	0.99
molecular function	0.96
transcription factor	0.69
transcription factor perturbation	0.68

Protein Classes

PANTHER Classes

Protein / Transferase / Kinase / Inositol Hexakisphosphate Kinase 2

DTO Classes

Protein / Kinase / Unclassified Protein / Inositol Hexakisphosphate Kinase 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.22   (req: < 5)

Gene RIFs: 11   (req: <= 3)

Antibodies: 187   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.22   (req: >= 5)

Gene RIFs: 11   (req: > 3)

Antibodies: 187   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0