Tbio DCDC2 Doublecortin domain-containing protein 2

Protein Summary

Description

Protein that plays a role in the inhibition of canonical Wnt signaling pathway (PubMed:25557784). May be involved in neuronal migration during development of the cerebral neocortex (By similarity). Involved in the control of ciliogenesis and ciliary length (PubMed:25601850, PubMed:27319779). This gene encodes a doublecortin domain-containing family member. The doublecortin domain has been demonstrated to bind tubulin and enhance microtubule polymerization. This family member is thought to function in neuronal migration where it may affect the signaling of primary cilia. Mutations in this gene have been associated with reading disability (RD) type 2, also referred to as developmental dyslexia. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jan 2013]

Uniprot Accession IDs

• Q9UHG0
• Q5VTR8
• Q5VTR9
• Q86W35
• Q9UFD1
• Q9UHG1
• Q9ULR6

Gene Name

• DCDC2

Ensembl ID

• ENST00000378450
• ENSP00000367711
• ENSG00000146038
• ENST00000378454
• ENSP00000367715

Symbol

• KIAA1154
• RU2
• NSC
• RU2
• RU2S
• DCDC2A
• DFNB66
• NPHP19

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.64
cell type or tissue	0.61
trait	0.61
phenotype	0.55
microRNA	0.52

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 330.59   (req: < 5)

Gene RIFs: 57   (req: <= 3)

Antibodies: 229   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 330.59   (req: >= 5)

Gene RIFs: 57   (req: > 3)

Antibodies: 229   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0