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Tbio
DCDC2
Doublecortin domain-containing protein 2

Protein Summary
Description
Protein that plays a role in the inhibition of canonical Wnt signaling pathway (PubMed:25557784). May be involved in neuronal migration during development of the cerebral neocortex (By similarity). Involved in the control of ciliogenesis and ciliary length (PubMed:25601850, PubMed:27319779). This gene encodes a doublecortin domain-containing family member. The doublecortin domain has been demonstrated to bind tubulin and enhance microtubule polymerization. This family member is thought to function in neuronal migration where it may affect the signaling of primary cilia. Mutations in this gene have been associated with reading disability (RD) type 2, also referred to as developmental dyslexia. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jan 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000378450
  • ENSP00000367711
  • ENSG00000146038
  • ENST00000378454
  • ENSP00000367715

Symbol
  • KIAA1154
  • RU2
  • NSC
  • RU2
  • RU2S
  • DCDC2A
  • DFNB66
  • NPHP19
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.64
cell type or tissue
0.61
trait
0.61
phenotype
0.55
microRNA
0.52


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 250.66   (req: < 5)
Gene RIFs: 46   (req: <= 3)
Antibodies: 229   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 250.66   (req: >= 5)
Gene RIFs: 46   (req: > 3)
Antibodies: 229   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
unipolar depression
1
1
0
1.1
59.2
wellbeing measurement
1
1
1
43.6
intelligence
1
1
0
6.3
30.8
glomerular filtration rate
2
1
1
5.5
11.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
unipolar depression
0
1.1
59.2
wellbeing measurement
1
43.6
intelligence
0
6.3
30.8
glomerular filtration rate
1
5.5
11.3
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
doublecortin domain containing 2
VGNC:11054
101057868
Macaque
doublecortin domain containing 2
707472
Mouse
MGI:2652818
195208
Rat
RGD:1310227
291130
Dog
doublecortin domain containing 2
VGNC:39800
488244
Species
Name
OMA
EggNOG
Inparanoid
Chimp
doublecortin domain containing 2
Macaque
doublecortin domain containing 2
Mouse
Rat
Dog
doublecortin domain containing 2
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (20)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (68)
1 – 10 of 68
KIAA0319
Tbio
Novelty: 0.01425914
Score: 0.926
Data Source: STRINGDB
DNAAF4
Tbio
Novelty: 0.01730685
Score: 0.909
Data Source: STRINGDB
KAAG1
Tdark
Novelty: 0.97046572
Score: 0.82
Data Source: STRINGDB
GCFC2
Tbio
Novelty: 0.04245608
Score: 0.766
Data Source: STRINGDB
NFXL1
Tdark
Family: TF
Novelty: 0.1573945
Score: 0.744
Data Source: STRINGDB
ACOT13
Tbio
Family: Enzyme
Novelty: 0.04119879
Score: 0.741
Data Source: STRINGDB
ROBO1
Tbio
Novelty: 0.00494884
Score: 0.732
Data Source: STRINGDB
MRPL19
Tbio
Novelty: 0.04235101
Score: 0.726
Data Source: STRINGDB
ATP2C2
Tbio
Family: Transporter
Novelty: 0.03299453
Score: 0.706
Data Source: STRINGDB
CMIP
Tbio
Novelty: 0.0076969
Score: 0.688
Data Source: STRINGDB
Publication Statistics
PubMed Score  250.66

PubMed score by year
PubTator Score  128.52

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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