Protein Summary
Stimulates the release of tumor necrosis factor alpha and IL-1-beta from the monocytic cell line THP-1. The protein encoded by this gene is a T cell-derived cytokine that shares sequence similarity with IL17. This cytokine was reported to stimulate the release of TNF alpha (TNF) and IL1 beta (IL1B) from a monocytic cell line. Immunohistochemical analysis of several nerve tissues indicated that this cytokine is primarily localized to neuronal cell bodies. Alternative splicing results in multiple splice variants. [provided by RefSeq, Dec 2015]
- ENST00000261796
- ENSP00000261796
- ENSG00000127743
- IL20
- NIRF
- ZCYTO7
- NIRF
- IL-20
- IL-17B
- ZCYTO7
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
gene perturbation | 0.76 | ||
virus perturbation | 0.64 | ||
cell type or tissue | 0.63 | ||
PubMedID | 0.6 | ||
chemical | 0.41 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 20.26 (req: < 5)
Gene RIFs: 12 (req: <= 3)
Antibodies: 400 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 20.26 (req: >= 5)
Gene RIFs: 12 (req: > 3)
Antibodies: 400 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Pathways (6)
KEGG (2)
WikiPathways (4)
Items per page:
1 – 2 of 2
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
KEGG | IL-17 signaling pathway | ||||
KEGG | Cytokine-cytokine receptor interaction | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
IL-17 signaling pathway | ||||
Cytokine-cytokine receptor interaction | ||||
Gene Ontology Terms (6)
Functions (1)
Components (1)
Processes (4)
Items per page:
10
1 – 1 of 1
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Traceable Author Statement (TAS) | ProtInc | |||
Protein-Protein Interactions (45)
1 – 10 of 45
DPH2
Novelty: 0.09916185
p_int: 0.999995572
p_ni: 0.000004428
Data Source: BioPlex
HIST1H1C
Novelty: 0.00937936
p_int: 0.999839163
p_ni: 0.000160837
Data Source: BioPlex
KBTBD7
Novelty: 1.01449275
p_int: 0.999582397
p_ni: 0.000417603
Data Source: BioPlex
ERBIN
Novelty: 0.01835002
p_int: 0.99875709
p_ni: 0.00124291
Data Source: BioPlex
DPH1
Novelty: 0.02897945
p_int: 0.998665493
p_ni: 0.001332996
p_wrong: 0.000001512
Data Source: BioPlex
TTL
Family: Enzyme
Novelty: 0.05571031
p_int: 0.99381464
p_ni: 0.006170764
p_wrong: 0.000014595
Data Source: BioPlex
MYEF2
Novelty: 0.336
p_int: 0.971722844
p_ni: 0.028277156
Data Source: BioPlex
STAU1
Novelty: 0.00542197
p_int: 0.961249743
p_ni: 0.038750257
Data Source: BioPlex
RSPRY1
Novelty: 0.46153846
p_int: 0.960639537
p_ni: 0.039360448
p_wrong: 1.5e-8
Data Source: BioPlex
RBM28
Novelty: 0.01991731
p_int: 0.949567974
p_ni: 0.050432026
Data Source: BioPlex
Publication Statistics
PubMed Score 20.26
PubMed score by year
PubTator Score 46.16
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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