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Tbio
IL17B
Interleukin-17B

Protein Summary
Description
Stimulates the release of tumor necrosis factor alpha and IL-1-beta from the monocytic cell line THP-1. The protein encoded by this gene is a T cell-derived cytokine that shares sequence similarity with IL17. This cytokine was reported to stimulate the release of TNF alpha (TNF) and IL1 beta (IL1B) from a monocytic cell line. Immunohistochemical analysis of several nerve tissues indicated that this cytokine is primarily localized to neuronal cell bodies. Alternative splicing results in multiple splice variants. [provided by RefSeq, Dec 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261796
  • ENSP00000261796
  • ENSG00000127743

Symbol
  • IL20
  • NIRF
  • ZCYTO7
  • NIRF
  • IL-20
  • IL-17B
  • ZCYTO7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.76
virus perturbation
0.64
cell type or tissue
0.63
PubMedID
0.6
chemical
0.41


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.26   (req: < 5)
View Publications
Gene RIFs: 12   (req: <= 3)
View Gene RIFs
Antibodies: 400   (req: <= 50)
View Antibodies
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.26   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 400   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
View GO Terms
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Gene Ontology Terms (6)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
cytokine activity
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (45)
1 – 10 of 45
DPH2
Tbio
Novelty: 0.09916185
p_int: 0.999995572
p_ni: 0.000004428
Data Source: BioPlex
HIST1H1C
Tbio
Novelty: 0.00937936
p_int: 0.999839163
p_ni: 0.000160837
Data Source: BioPlex
KBTBD7
Tdark
Novelty: 1.01449275
p_int: 0.999582397
p_ni: 0.000417603
Data Source: BioPlex
ERBIN
Tbio
Novelty: 0.01835002
p_int: 0.99875709
p_ni: 0.00124291
Data Source: BioPlex
DPH1
Tbio
Novelty: 0.02897945
p_int: 0.998665493
p_ni: 0.001332996
p_wrong: 0.000001512
Data Source: BioPlex
TTL
Tchem
Family: Enzyme
Novelty: 0.05571031
p_int: 0.99381464
p_ni: 0.006170764
p_wrong: 0.000014595
Data Source: BioPlex
MYEF2
Tdark
Novelty: 0.336
p_int: 0.971722844
p_ni: 0.028277156
Data Source: BioPlex
STAU1
Tbio
Novelty: 0.00542197
p_int: 0.961249743
p_ni: 0.038750257
Data Source: BioPlex
RSPRY1
Tdark
Novelty: 0.46153846
p_int: 0.960639537
p_ni: 0.039360448
p_wrong: 1.5e-8
Data Source: BioPlex
RBM28
Tbio
Novelty: 0.01991731
p_int: 0.949567974
p_ni: 0.050432026
Data Source: BioPlex
Publication Statistics
PubMed Score  20.26

PubMed score by year
PubTator Score  46.16

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer