IL20RA
Interleukin-20 receptor subunit alpha
Protein Summary
The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL20RA/IL10RB dimer is a receptor for IL26. This gene encodes a member of the type II cytokine receptor family. The encoded protein is a subunit of the receptor for interleukin 20, a cytokine that may be involved in epidermal function. The interleukin 20 receptor is a heterodimeric complex consisting of the encoded protein and interleukin 20 receptor beta. This gene and interleukin 20 receptor beta are highly expressed in skin, and are upregulated in psoriasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
- ENST00000316649
- ENSP00000314976
- ENSG00000016402
- ENST00000367748
- ENSP00000356722
- ENST00000541547
- ENSP00000437843
- CRF2-8
- IL-20R1
- IL-20RA
- IL-20R-alpha
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
PubMedID | 0.63 | ||
trait | 0.61 | ||
protein domain | 0.58 | ||
gene perturbation | 0.56 | ||
histone modification site profile | 0.5 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 43.51 (req: < 5)
Gene RIFs: 14 (req: <= 3)
Antibodies: 333 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 43.51 (req: >= 5)
Gene RIFs: 14 (req: > 3)
Antibodies: 333 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0