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Tbio
IL20RA
Interleukin-20 receptor subunit alpha

Protein Summary
Description
The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL20RA/IL10RB dimer is a receptor for IL26. This gene encodes a member of the type II cytokine receptor family. The encoded protein is a subunit of the receptor for interleukin 20, a cytokine that may be involved in epidermal function. The interleukin 20 receptor is a heterodimeric complex consisting of the encoded protein and interleukin 20 receptor beta. This gene and interleukin 20 receptor beta are highly expressed in skin, and are upregulated in psoriasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000316649
  • ENSP00000314976
  • ENSG00000016402
  • ENST00000367748
  • ENSP00000356722
  • ENST00000541547
  • ENSP00000437843

Symbol
  • CRF2-8
  • IL-20R1
  • IL-20RA
  • IL-20R-alpha
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.63
trait
0.61
protein domain
0.58
gene perturbation
0.56
histone modification site profile
0.5


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.62   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 333   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.62   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 333   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (114)
TNIK
Tchem
Family:  Kinase
Novelty:  0.02681864
p_int:  0.999745016
p_ni:  0.000242022
p_wrong:  0.000012962
Score:  0.175
Data Source:  BioPlex,STRINGDB
UBB
Tbio
Novelty:  0.00661254
p_int:  0.999257465
p_ni:  0.000742535
Data Source:  BioPlex
NFRKB
Tbio
Novelty:  0.13445983
p_int:  0.999245718
p_ni:  0.000754282
Data Source:  BioPlex
LAPTM4B
Tbio
Novelty:  0.01162533
p_int:  0.998902121
p_ni:  0.000914146
p_wrong:  0.000183733
Data Source:  BioPlex
DIRAS1
Tbio
Family:  Enzyme
Novelty:  0.13332903
p_int:  0.997668921
p_ni:  0.00214713
p_wrong:  0.000183949
Data Source:  BioPlex
STAT3
Tchem
Family:  TF
Novelty:  0.00011808
p_int:  0.996430977
p_ni:  0.003569023
Score:  0.955
Data Source:  BioPlex,Reactome,STRINGDB
PIK3CA
Tclin
Family:  Kinase
Novelty:  0.00044273
p_int:  0.995638023
p_ni:  0.004361975
p_wrong:  2e-9
Data Source:  BioPlex
CYB5R1
Tbio
Family:  Enzyme
Novelty:  0.07714146
p_int:  0.994259009
p_ni:  0.005740991
Data Source:  BioPlex
CDC6
Tbio
Novelty:  0.00219371
p_int:  0.993525629
p_ni:  0.006474369
p_wrong:  2e-9
Data Source:  BioPlex
ROCK1
Tclin
Family:  Kinase
Novelty:  0.00156045
p_int:  0.992847769
p_ni:  0.00034861
p_wrong:  0.00680362
Score:  0.17
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets (9)
Explore Nearest Tclin Targets
Pathways (9)
Cytokine Signaling in Immune system (R-HSA-1280215)

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Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interleukin-20 family signaling
Reactome
Signaling by Interleukins
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interleukin-20 family signaling
Signaling by Interleukins
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (6)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
7
6
3
1.1
95.9
3
2
0
1.1
81.7
coffee consumption measurement
1
1
1
63.7
tea consumption measurement
2
1
2
63.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
1.1
95.9
0
1.1
81.7
coffee consumption measurement
1
63.7
tea consumption measurement
2
63.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
interleukin 20 receptor subunit alpha
VGNC:3242
463026
Macaque
interleukin 20 receptor subunit alpha
704890
Mouse
MGI:3605069
237313
Rat
RGD:1307335
308716
Dog
interleukin 20 receptor subunit alpha
VGNC:41965
484002
Species
Name
OMA
EggNOG
Inparanoid
Chimp
interleukin 20 receptor subunit alpha
Macaque
interleukin 20 receptor subunit alpha
Mouse
Rat
Dog
interleukin 20 receptor subunit alpha
Publication Statistics
PubMed Score 37.62
PubMed score by year
PubTator Score 18.40
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title