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Tchem
TAC3
Tachykinin-3

Protein Summary
Description
Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles (By similarity). Is a critical central regulator of gonadal function. This gene encodes a member of the tachykinin family of secreted neuropeptides. The encoded preproprotein is proteolytically processed to generate the mature peptide, which is primarily expressed in the central and peripheral nervous systems and functions as a neurotransmitter. This peptide is the ligand for the neurokinin-3 receptor. This protein is also expressed in the outer syncytiotrophoblast of the placenta and may be associated with pregnancy-induced hypertension and pre-eclampsia. Mutations in this gene are associated with normosmic hypogonadotropic hypogonadism. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000300108
  • ENSP00000300108
  • ENSG00000166863
  • ENST00000357616
  • ENSP00000350236
  • ENST00000379411
  • ENSP00000368721
  • ENST00000393867
  • ENSP00000377445
  • ENST00000415231
  • ENSP00000402995
  • ENST00000423597
  • ENSP00000416292
  • ENST00000438756
  • ENSP00000408131
  • ENST00000441881
  • ENSP00000408208
  • ENST00000458521
  • ENSP00000404056
  • ENST00000615887
  • ENSP00000483110

Symbol
  • NKNB
  • NKB
  • HH10
  • NKNB
  • PRO1155
  • ZNEUROK1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.72
gene perturbation
0.6
biological term
0.56
disease perturbation
0.56
pathway
0.52


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 625.44   (req: < 5)
Gene RIFs: 42   (req: <= 3)
Antibodies: 248   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 625.44   (req: >= 5)
Gene RIFs: 42   (req: > 3)
Antibodies: 248   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 6
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (201)
O43687
Tbio
Family:  Enzyme
Novelty:  0.04114095
p_int:  0.999623971
p_ni:  0.000375849
p_wrong:  1.81e-7
Data Source:  BioPlex
EMC4
Tbio
Novelty:  0.12174476
p_int:  0.940166647
p_ni:  0.059448287
p_wrong:  0.000385066
Data Source:  BioPlex
TACR3
Tchem
Family:  GPCR
Novelty:  0.00351352
Score:  0.997
Data Source:  Reactome,STRINGDB
TACR2
Tchem
Family:  GPCR
Novelty:  0.00194306
Score:  0.993
Data Source:  STRINGDB
TACR1
Tclin
Family:  GPCR
Novelty:  0.00062762
Score:  0.991
Data Source:  STRINGDB
TAC1
Tbio
Novelty:  0.00006575
Score:  0.991
Data Source:  STRINGDB
KISS1
Tbio
Novelty:  0.00096537
Score:  0.988
Data Source:  STRINGDB
GNRH1
Tbio
Novelty:  0.00020807
Score:  0.986
Data Source:  STRINGDB
KISS1R
Tchem
Family:  GPCR
Novelty:  0.0026282
Score:  0.979
Data Source:  STRINGDB
NPS
Tbio
Novelty:  0.00692108
Score:  0.972
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (15)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Peptide ligand-binding receptors
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (q) signalling events
GPCR downstream signalling
GPCR ligand binding
Peptide ligand-binding receptors
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (31)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
asthma
12
8
1
1.1
98.8
allergic disease
5
2
2
1.1
93.9
adult onset asthma
2
2
0
1.1
91.4
childhood onset asthma
2
1
0
1.1
87.3
Eczema
2
1
0
1.1
81.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
asthma
1
1.1
98.8
allergic disease
2
1.1
93.9
adult onset asthma
0
1.1
91.4
childhood onset asthma
0
1.1
87.3
Eczema
0
1.1
81.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
tachykinin 3
713978
Mouse
MGI:98476
21334
Rat
RGD:3809
29191
Dog
tachykinin 3
VGNC:47062
607315
Cow
tachykinin 3
VGNC:35556
281513
Species
Name
OMA
EggNOG
Inparanoid
Macaque
tachykinin 3
Mouse
Rat
Dog
tachykinin 3
Cow
tachykinin 3
Publication Statistics
PubMed Score 625.44
PubMed score by year
PubTator Score 261.48
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title