Tbio STEAP1 Metalloreductase STEAP1

Protein Summary

Description

Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor (By similarity). This gene is predominantly expressed in prostate tissue, and is found to be upregulated in multiple cancer cell lines. The gene product is predicted to be a six-transmembrane protein, and was shown to be a cell surface antigen significantly expressed at cell-cell junctions. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9UHE8
• A4D1E0
• O95034

Gene Name

• STEAP1

Ensembl ID

• ENST00000297205
• ENSP00000297205
• ENSG00000164647

Symbol

• PRSS24
• STEAP
• STEAP
• PRSS24

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.94
kinase perturbation	0.81
transcription factor perturbation	0.8
cell type or tissue	0.7
cellular component	0.7

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 79.24   (req: < 5)

Gene RIFs: 34   (req: <= 3)

Antibodies: 386   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 79.24   (req: >= 5)

Gene RIFs: 34   (req: > 3)

Antibodies: 386   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0