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Tbio
NAT8
N-acetyltransferase 8

Protein Summary
Description
Acetylates the free alpha-amino group of cysteine S-conjugates to form mercapturic acids (PubMed:20392701). This is the final step in a major route for detoxification of a wide variety of reactive electrophiles which starts with their incorporation into glutathione S-conjugates. The glutathione S-conjugates are then further processed into cysteine S-conjugates and finally mercapturic acids which are water soluble and can be readily excreted in urine or bile. Alternatively, may have a lysine N-acetyltransferase activity catalyzing peptidyl-lysine N6-acetylation of various proteins. Thereby, may regulate apoptosis through the acetylation and the regulation of the expression of PROM1 (PubMed:24556617). May also regulate amyloid beta-peptide secretion through acetylation of BACE1 and the regulation of its expression in neurons (PubMed:19011241). This gene, isolated using the differential display method to detect tissue-specific genes, is specifically expressed in kidney and liver. The enco ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000272425
  • ENSP00000272425
  • ENSG00000144035

Symbol
  • CML1
  • GLA
  • TSC501
  • GLA
  • CML1
  • CCNAT
  • Hcml1
  • ATase2
  • TSC501
  • TSC510
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.74
phenotype
0.59
tissue
0.57
cellular component
0.56
cell type or tissue
0.54


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.17   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 213   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.17   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 213   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urinary metabolite measurement
4
9
14
99.8
serum metabolite measurement
3
7
10
99.3
glomerular filtration rate
6
5
5
10.3
98.2
blood metabolite measurement
3
3
7
98.2
metabolite measurement
3
3
3
96.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urinary metabolite measurement
14
99.8
serum metabolite measurement
10
99.3
glomerular filtration rate
5
10.3
98.2
blood metabolite measurement
7
98.2
metabolite measurement
3
96.9
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
N-acetyltransferase 8 (putative)
470406
Dog
N-acetyltransferase 8 (putative)
100856478
Horse
putative N-acetyltransferase 8B
100058571
Xenopus
nat8 protein
XB-GENE-5771028
493291
Species
Name
OMA
EggNOG
Inparanoid
Chimp
N-acetyltransferase 8 (putative)
Dog
N-acetyltransferase 8 (putative)
Horse
putative N-acetyltransferase 8B
Xenopus
nat8 protein
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9UHE5-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (6)
Amyloid fiber formation (R-HSA-977225)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amyloid fiber formation
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Amyloid fiber formation
Metabolism of proteins
Protein-Protein Interactions (37)
1 – 10 of 37
NAT8B
Tbio
Family:  Enzyme
p_int:  0.98906579
p_ni:  5e-9
p_wrong:  0.010934205
Data Source:  BioPlex
ANPEP
Tchem
Family:  Enzyme
Novelty:  0.0004182
Score:  0.929
Data Source:  STRINGDB
BACE1
Tchem
Family:  Enzyme
Novelty:  0.00042175
Score:  0.926
Data Source:  Reactome,STRINGDB
LAP3
Tchem
Family:  Enzyme
Novelty:  0.00327467
Score:  0.9
Data Source:  STRINGDB
KAT2A
Tchem
Family:  Epigenetic
Novelty:  0.00238831
Score:  0.777
Data Source:  STRINGDB
KAT2B
Tchem
Family:  Epigenetic
Novelty:  0.00172126
Score:  0.749
Data Source:  STRINGDB
PYROXD2
Tbio
Family:  Enzyme
Novelty:  0.18643536
Score:  0.654
Data Source:  STRINGDB
NAA25
Tbio
Family:  Enzyme
Novelty:  0.05422122
Score:  0.638
Data Source:  STRINGDB
NAA20
Tbio
Family:  Enzyme
Novelty:  0.07814789
Score:  0.634
Data Source:  STRINGDB
NAA35
Tbio
Family:  Enzyme
Novelty:  0.04980045
Score:  0.609
Data Source:  STRINGDB
Publication Statistics
PubMed Score  50.17

PubMed score by year
PubTator Score  32.57

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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