Tbio UBQLN2 Ubiquilin-2

Protein Summary

Description

Plays an important role in the regulation of different protein degradation mechanisms and pathways including ubiquitin-proteasome system (UPS), autophagy and the endoplasmic reticulum-associated protein degradation (ERAD) pathway. Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome (PubMed:10983987). Plays a role in the ERAD pathway via its interaction with ER-localized proteins FAF2/UBXD8 and HERPUD1 and may form a link between the polyubiquitinated ERAD substrates and the proteasome (PubMed:24215460, PubMed:18307982). Involved in the regulation of macroautophagy and autophagosome formation; required for maturation of autophagy-related protein LC3 from the cytosolic form LC3-I to the membrane-bound form LC3-II and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion (PubMed:19148225, PubMed:20529957). Negatively regulates the endocytosis of GPCR receptors: AVPR2 and ADRB2, by specifically reducing the rate at which receptor-arrestin complexes concentrate in clathrin-coated pits (CCPs) (PubMed:18199683). This gene encodes an ubiquitin-like protein (ubiquilin) that shares high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain a N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases; and thus, are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This ubiquilin has also been shown to bind the ATPase domain of the Hsp70-like Stch protein. [provided by RefSeq, Oct 2009]

Uniprot Accession IDs

• Q9UHD9
• O94798
• Q5D027
• Q9H3W6
• Q9HAZ4

Gene Name

• UBQLN2

Ensembl ID

• ENST00000338222
• ENSP00000345195
• ENSG00000188021

Symbol

• N4BP4
• PLIC2
• DSK2
• ALS15
• CHAP1
• N4BP4
• PLIC2
• HRIHFB2157

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.99
virus perturbation	0.98
transcription factor perturbation	0.91
kinase perturbation	0.84
disease perturbation	0.68

Related Tools

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 131.49   (req: < 5)

Gene RIFs: 49   (req: <= 3)

Antibodies: 242   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 131.49   (req: >= 5)

Gene RIFs: 49   (req: > 3)

Antibodies: 242   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Orthologs (4)

1 – 4 of 4

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Mouse	ubiquilin 2	MGI:1860283	54609
Rat	ubiquilin 2	RGD:1563566	317396
Dog	ubiquilin 2	VGNC:48085	491909
Cow	ubiquilin 2	VGNC:36614	539529

Species	Name	OMA	EggNOG	Inparanoid
Mouse	ubiquilin 2
Rat	ubiquilin 2
Dog	ubiquilin 2
Cow	ubiquilin 2

Protein Structure (2 Structures, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9UHD9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (5)

Reactome (4)

KEGG (1)

Cargo recognition for clathrin-mediated endocytosis (R-HSA-8856825)

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Items per page:

5

1 – 4 of 4

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cargo recognition for clathrin-mediated endocytosis	105 targets	R-HSA-8856825
Reactome	Clathrin-mediated endocytosis	143 targets	R-HSA-8856828
Reactome	Membrane Trafficking	612 targets	R-HSA-199991
Reactome	Vesicle-mediated transport	725 targets	R-HSA-5653656

Name	Explore in Pharos	Explore in Source
Cargo recognition for clathrin-mediated endocytosis	105 targets	R-HSA-8856825
Clathrin-mediated endocytosis	143 targets	R-HSA-8856828
Membrane Trafficking	612 targets	R-HSA-199991
Vesicle-mediated transport	725 targets	R-HSA-5653656

Gene Ontology Terms (13)

Components (6)

Processes (7)

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Items per page:

10

1 – 6 of 6

GO Term	Evidence	Assigned by
cytoplasm	Inferred from Direct Assay (IDA)	UniProtKB
cytosol	Inferred from Direct Assay (IDA)	HPA
plasma membrane	Inferred from Direct Assay (IDA)	HPA
autophagosome	Inferred from Electronic Annotation (IEA)	UniProtKB-SubCell
cytoplasmic vesicle	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
nucleus	Inferred from Electronic Annotation (IEA)	UniProtKB-SubCell

Protein-Protein Interactions (323)

Explore Interacting Targets

1 – 10 of 323

• See Interactions on String-DB

TMEM31

Tdark

Novelty: 0.65381391

p_int: 0.986737183

p_ni: 0.013262817

Data Source: BioPlex

SLC17A2

Tdark

Family: Transporter

Novelty: 0.23941275

p_int: 0.808123376

p_ni: 0.191876622

p_wrong: 2e-9

Score: 0.235

Data Source: BioPlex,STRINGDB

STAM

Tbio

Novelty: 0.0332731

Score: 0.985

Data Source: STRINGDB

UBA52

Tbio

Novelty: 0.01637744

Score: 0.978

Data Source: STRINGDB

UBC

Tbio

Novelty: 0.00204643

Score: 0.965

Data Source: STRINGDB

EPS15

Tbio

Novelty: 0.00451447

Score: 0.954

Data Source: Reactome,STRINGDB

UBL7

Tdark

Novelty: 0.20935024

Score: 0.952

Data Source: STRINGDB

RPS27A

Tbio

Novelty: 0.00658124

Score: 0.947

Data Source: STRINGDB

PSMD4

Tbio

Family: Enzyme

Novelty: 0.00614538

Score: 0.945

Data Source: STRINGDB

UBB

Tbio

Novelty: 0.00661254

Score: 0.945

Data Source: STRINGDB

Publication Statistics

PubMed Score  131.49

PubMed score by year

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PubTator Score  65.17

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

3D-structure
Acetylation
Amyotrophic lateral sclerosis
Autophagy
Complete proteome
Cytoplasm
Cytoplasmic vesicle
Disease mutation
Membrane
Neurodegeneration