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Tchem
SEPT9
Septin-9

Protein Summary
Description
Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in the internalization of 2 intracellular microbial pathogens, Listeria monocytogenes and Shigella flexneri. This gene is a member of the septin family involved in cytokinesis and cell cycle control. This gene is a candidate for the ovarian tumor suppressor gene. Mutations in this gene cause hereditary neuralgic amyotrophy, also known as neuritis with brachial predilection. A chromosomal translocation involving this gene on chromosome 17 and the MLL gene on chromosome 11 results in acute myelomonocytic leukemia. Multiple alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Mar 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000329047
  • ENSP00000329161
  • ENSG00000184640
  • ENST00000423034
  • ENSP00000405877
  • ENST00000427177
  • ENSP00000391249
  • ENST00000427180
  • ENSP00000415624
  • ENST00000427674
  • ENSP00000403194
  • ENST00000431235
  • ENSP00000406987
  • ENST00000449803
  • ENSP00000400181
  • ENST00000541152
  • ENSP00000438089
  • ENST00000585930
  • ENSP00000468120
  • ENST00000588690
  • ENSP00000468668
  • ENST00000590294
  • ENSP00000465464
  • ENST00000591088
  • ENSP00000466247
  • ENST00000591198
  • ENSP00000468406
  • ENST00000592951
  • ENSP00000466648

Symbol
  • KIAA0991
  • MSF
  • MSF
  • MSF1
  • NAPB
  • SINT1
  • PNUTL4
  • SeptD1
  • AF17q25
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
molecular function
0.91
disease perturbation
0.83
kinase perturbation
0.81
transcription factor perturbation
0.8


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 341.68   (req: < 5)
Gene RIFs: 107   (req: <= 3)
Antibodies: 181   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 341.68   (req: >= 5)
Gene RIFs: 107   (req: > 3)
Antibodies: 181   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1