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Tchem
TBK1
Serine/threonine-protein kinase TBK1

Protein Summary
Description
Serine/threonine kinase that plays an essential role in regulating inflammatory responses to foreign agents. Following activation of toll-like receptors by viral or bacterial components, associates with TRAF3 and TANK and phosphorylates interferon regulatory factors (IRFs) IRF3 and IRF7 as well as DDX3X. This activity allows subsequent homodimerization and nuclear translocation of the IRFs leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNA and IFNB. In order to establish such an antiviral state, TBK1 form several different complexes whose composition depends on the type of cell and cellular stimuli. Thus, several scaffolding molecules including FADD, TRADD, MAVS, AZI2, TANK or TBKBP1/SINTBAD can be recruited to the TBK1-containing-complexes. Under particular conditions, functions as a NF-kappa-B effector by phosphorylating NF-kappa-B inhibitor alpha/NFKBIA, IKBKB or RELA to translocate NF-Kappa-B to the nucleus. Restricts bacterial proliferatio ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000331710
  • ENSP00000329967
  • ENSG00000183735

Symbol
  • NAK
  • NAK
  • T2K
  • IIAE8
  • FTDALS4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
disease perturbation
0.99
biological process
0.95
molecular function
0.94
histone modification site profile
0.89


Related Tools
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 538.82   (req: < 5)
Gene RIFs: 150   (req: <= 3)
Antibodies: 571   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 538.82   (req: >= 5)
Gene RIFs: 150   (req: > 3)
Antibodies: 571   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 34
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 87
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
midostaurin
chemical structure image
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.2
50.9
mean corpuscular hemoglobin concentration
1
1
1
45.1
reticulocyte count
2
1
2
1.6
reticulocyte measurement
2
1
2
0.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
50.9
mean corpuscular hemoglobin concentration
1
45.1
reticulocyte count
2
1.6
reticulocyte measurement
2
0.9
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TANK binding kinase 1
VGNC:8581
452047
Macaque
TANK binding kinase 1
717427
Mouse
MGI:1929658
56480
Rat
RGD:1588588
299827
Dog
TANK binding kinase 1
VGNC:47160
481145
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TANK binding kinase 1
Macaque
TANK binding kinase 1
Mouse
Rat
Dog
TANK binding kinase 1
Protein Structure (17 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9UHD2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 17
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (55)
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon (R-HSA-936964)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 24
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
Reactome
Cytokine Signaling in Immune system
Reactome
Cytosolic sensors of pathogen-associated DNA
Reactome
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Reactome
IRF3 mediated activation of type 1 IFN
Name
Explore in Pharos
Explore in Source
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
Cytokine Signaling in Immune system
Cytosolic sensors of pathogen-associated DNA
DDX58/IFIH1-mediated induction of interferon-alpha/beta
IRF3 mediated activation of type 1 IFN
Gene Ontology Terms (39)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
ARUK-UCL
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (250)
1 – 10 of 250
BBOX1
Tchem
Family: Enzyme
Novelty: 0.00255489
p_int: 0.999997818
p_ni: 0.000002182
Score: 0.643
Data Source: BioPlex,STRINGDB
TRAF1
Tbio
Novelty: 0.00526776
p_int: 0.999995929
p_ni: 0.000004071
Score: 0.499
Data Source: BioPlex,STRINGDB
CALCOCO2
Tbio
Novelty: 0.01456844
p_int: 0.999991201
p_ni: 0.000008799
Score: 0.986
Data Source: BioPlex,STRINGDB
TRAF2
Tbio
Novelty: 0.00983658
p_int: 0.99996442
p_ni: 0.00003558
Score: 0.989
Data Source: BioPlex,Reactome,STRINGDB
TXLNA
Tbio
Novelty: 0.02549959
p_int: 0.99994427
p_ni: 0.000055731
Score: 0.693
Data Source: BioPlex,STRINGDB
STX12
Tbio
Novelty: 0.03836262
p_int: 0.999932305
p_ni: 0.000067694
p_wrong: 1e-9
Score: 0.19
Data Source: BioPlex,STRINGDB
PIP
Tbio
Novelty: 0.00208509
p_int: 0.999880973
p_ni: 0.000119027
Data Source: BioPlex
STX11
Tbio
Novelty: 0.01670743
p_int: 0.999854935
p_ni: 0.000145062
p_wrong: 2e-9
Score: 0.163
Data Source: BioPlex,STRINGDB
BLOC1S6
Tbio
Novelty: 0.01845286
p_int: 0.999562535
p_ni: 0.000437465
Data Source: BioPlex
APBA3
Tbio
Novelty: 0.05059532
p_int: 0.99942505
p_ni: 0.000574866
p_wrong: 8.5e-8
Score: 0.536
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  538.82

PubMed score by year
PubTator Score  487.04

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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