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Tbio
CHORDC1
Cysteine and histidine-rich domain-containing protein 1

Protein Summary
Description
Regulates centrosome duplication, probably by inhibiting the kinase activity of ROCK2. Proposed to act as co-chaperone for HSP90. May play a role in the regulation of NOD1 via a HSP90 chaperone complex. In vitro, has intrinsic chaperone activity. This function may be achieved by inhibiting association of ROCK2 with NPM1. Involved in stress response. Prevents tumorigenesis.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000320585
  • ENSP00000319255
  • ENSG00000110172
  • ENST00000457199
  • ENSP00000401080
  • ENST00000646618
  • ENSP00000496744
  • ENSG00000285023
  • ENST00000647220
  • ENSP00000494044

Symbol
  • CHP1
  • CHP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.79
small molecule perturbation
0.77
virus perturbation
0.64
microRNA
0.61
cell type or tissue
0.6


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.72   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 187   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.72   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 187   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0