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Tbio
CHORDC1
Cysteine and histidine-rich domain-containing protein 1

Protein Summary
Description
Regulates centrosome duplication, probably by inhibiting the kinase activity of ROCK2. Proposed to act as co-chaperone for HSP90. May play a role in the regulation of NOD1 via a HSP90 chaperone complex. In vitro, has intrinsic chaperone activity. This function may be achieved by inhibiting association of ROCK2 with NPM1. Involved in stress response. Prevents tumorigenesis.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000320585
  • ENSP00000319255
  • ENSG00000110172
  • ENST00000457199
  • ENSP00000401080
  • ENST00000646618
  • ENSP00000496744
  • ENSG00000285023
  • ENST00000647220
  • ENSP00000494044

Symbol
  • CHP1
  • CHP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.79
small molecule perturbation
0.77
virus perturbation
0.64
microRNA
0.61
cell type or tissue
0.6


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.49   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 187   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.49   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 187   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (64)
EDRF1
Tbio
Novelty:  0.24333657
p_int:  0.944055464
p_ni:  0.055916623
p_wrong:  0.000027913
Score:  0.571
Data Source:  BioPlex,STRINGDB
UNC5CL
Tbio
Novelty:  0.11511991
p_int:  0.940295685
p_ni:  0.059704228
p_wrong:  8.7e-8
Score:  0.188
Data Source:  BioPlex,STRINGDB
GTF2E2
Tbio
Novelty:  0.18033153
p_int:  0.826329574
p_ni:  0.173670426
Data Source:  BioPlex
VSIG2
Tdark
Novelty:  0.32398032
p_int:  0.823841746
p_ni:  0.176158057
p_wrong:  1.97e-7
Score:  0.175
Data Source:  BioPlex,STRINGDB
SNRNP27
Tbio
Novelty:  0.0175187
p_int:  0.817715439
p_ni:  0.182284552
p_wrong:  9e-9
Score:  0.192
Data Source:  BioPlex,STRINGDB
TTC4
Tbio
Novelty:  0.00808711
p_int:  0.79434598
p_ni:  0.20565402
Score:  0.818
Data Source:  BioPlex,STRINGDB
SUGT1
Tbio
Novelty:  0.1042721
Score:  0.919
Data Source:  STRINGDB
CHP1
Tbio
Novelty:  0.01299969
Score:  0.89
Data Source:  STRINGDB
PPP5C
Tbio
Family:  Enzyme
Novelty:  0.01990823
Score:  0.772
Data Source:  STRINGDB
HSP90AA1
Tchem
Novelty:  0.00016774
Score:  0.771
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
basophil count
3
3
3
80.9
body mass index
2
2
2
59.4
body height
1
1
1
56.4
basophil percentage of leukocytes
1
1
1
42.3
leukocyte count
1
1
1
33.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
basophil count
3
80.9
body mass index
2
59.4
body height
1
56.4
basophil percentage of leukocytes
1
42.3
leukocyte count
1
33.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cysteine and histidine rich domain containing 1
VGNC:3152
466743
Macaque
cysteine and histidine rich domain containing 1
694312
Mouse
MGI:1914167
66917
Rat
RGD:1304679
315447
Dog
cysteine and histidine rich domain containing 1
VGNC:39226
476773
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cysteine and histidine rich domain containing 1
Macaque
cysteine and histidine rich domain containing 1
Mouse
Rat
Dog
cysteine and histidine rich domain containing 1
Publication Statistics
PubMed Score 32.49
PubMed score by year
PubTator Score 6.15
PubTator score by year
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Related Publications
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PMID
Year
Title