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Tbio
CHORDC1
Cysteine and histidine-rich domain-containing protein 1

Protein Classes
Protein Summary
Description
Regulates centrosome duplication, probably by inhibiting the kinase activity of ROCK2. Proposed to act as co-chaperone for HSP90. May play a role in the regulation of NOD1 via a HSP90 chaperone complex. In vitro, has intrinsic chaperone activity. This function may be achieved by inhibiting association of ROCK2 with NPM1. Involved in stress response. Prevents tumorigenesis.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000320585
  • ENSP00000319255
  • ENSG00000110172
  • ENST00000457199
  • ENSP00000401080
  • ENST00000646618
  • ENSP00000496744
  • ENSG00000285023
  • ENST00000647220
  • ENSP00000494044

Symbol
  • CHP1
  • CHP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.79
small molecule perturbation
0.77
virus perturbation
0.64
microRNA
0.61
cell type or tissue
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.59   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 187   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.59   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 187   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (8)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (64)
1 – 10 of 64
EDRF1
Tdark
Novelty: 0.32061069
p_int: 0.944055464
p_ni: 0.055916623
p_wrong: 0.000027913
Score: 0.571
Data Source: BioPlex,STRINGDB
UNC5CL
Tbio
Novelty: 0.19528828
p_int: 0.940295685
p_ni: 0.059704228
p_wrong: 8.7e-8
Score: 0.188
Data Source: BioPlex,STRINGDB
GTF2E2
Tbio
Novelty: 0.16730745
p_int: 0.826329574
p_ni: 0.173670426
Data Source: BioPlex
VSIG2
Tdark
Novelty: 0.71794872
p_int: 0.823841746
p_ni: 0.176158057
p_wrong: 1.97e-7
Score: 0.175
Data Source: BioPlex,STRINGDB
SNRNP27
Tbio
Novelty: 0.00944493
p_int: 0.817715439
p_ni: 0.182284552
p_wrong: 9e-9
Score: 0.192
Data Source: BioPlex,STRINGDB
TTC4
Tbio
Novelty: 0.01189394
p_int: 0.79434598
p_ni: 0.20565402
Score: 0.818
Data Source: BioPlex,STRINGDB
SUGT1
Tbio
Novelty: 0.17606795
Score: 0.919
Data Source: STRINGDB
CHP1
Tbio
Novelty: 0.02100823
Score: 0.89
Data Source: STRINGDB
PPP5C
Tbio
Family: Enzyme
Novelty: 0.01846566
Score: 0.772
Data Source: STRINGDB
HSP90AA1
Tchem
Novelty: 0.00020424
Score: 0.771
Data Source: STRINGDB
Publication Statistics
PubMed Score  29.59

PubMed score by year
PubTator Score  6.15

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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