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Tclin
NPC1L1
NPC1-like intracellular cholesterol transporter 1

Protein Summary
Description
Plays a major role in cholesterol homeostasis. Is critical for the uptake of cholesterol across the plasma membrane of the intestinal enterocyte. Is the direct molecular target of ezetimibe, a drug that inhibits cholesterol absorption. Lack of activity leads to multiple lipid transport defects. The protein may have a function in the transport of multiple lipids and their homeostasis, and may play a critical role in regulating lipid metabolism. Acts as a negative regulator of NPC2 and down-regulates its expression and secretion by inhibiting its maturation and accelerating its degradation. The protein encoded by this gene is a multi-pass membrane protein. It contains a conserved N-terminal Niemann-Pick C1 (NPC1) domain and a putative sterol-sensing domain (SSD) which includes a YQRL motif functioning as a plasma membrane to trans-Golgi network transport signal in other proteins. This protein takes up free cholesterol into cells through vesicular endocytosis and plays a critical role in ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000289547
  • ENSP00000289547
  • ENSG00000015520
  • ENST00000423141
  • ENSP00000404670

Symbol
  • LDLCQ7
  • NPC11L1
  • SLC65A2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.81
cellular component
0.65
biological term
0.64
molecular function
0.63
tissue sample
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 330.62   (req: < 5)
Gene RIFs: 79   (req: <= 3)
Antibodies: 182   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 330.62   (req: >= 5)
Gene RIFs: 79   (req: > 3)
Antibodies: 182   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 20
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (67)
SREBF2
Tchem
Family:  TF
Novelty:  0.00171709
Score:  0.902
Data Source:  STRINGDB
ABCG5
Tbio
Family:  Transporter
Novelty:  0.00340812
Score:  0.899
Data Source:  STRINGDB
ABCG8
Tbio
Family:  Transporter
Novelty:  0.00431518
Score:  0.882
Data Source:  STRINGDB
SCARB1
Tchem
Novelty:  0.00087703
Score:  0.804
Data Source:  STRINGDB
CYP7A1
Tchem
Family:  Enzyme
Novelty:  0.00148194
Score:  0.763
Data Source:  STRINGDB
ABCA1
Tclin
Family:  Transporter
Novelty:  0.00059241
Score:  0.736
Data Source:  STRINGDB
SREBF1
Tbio
Family:  TF
Novelty:  0.00055257
Score:  0.72
Data Source:  STRINGDB
PCSK9
Tclin
Family:  Enzyme
Novelty:  0.00030553
Score:  0.703
Data Source:  STRINGDB
MTTP
Tclin
Novelty:  0.00212548
Score:  0.701
Data Source:  STRINGDB
APOB
Tchem
Novelty:  0.00008247
Score:  0.694
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Digestion and absorption (R-HSA-8963743)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Digestion and absorption
Reactome
Intestinal absorption
Reactome
Intestinal lipid absorption
Name
Explore in Pharos
Explore in Source
Digestion and absorption
Intestinal absorption
Intestinal lipid absorption
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (15)
Find Similar Targets
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
9
9
19
99.1
total cholesterol measurement
6
6
8
89.8
hip bone size
1
1
1
54.4
HbA1c measurement
1
1
1
49.5
apolipoprotein B measurement
1
1
1
41.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
19
99.1
total cholesterol measurement
8
89.8
hip bone size
1
54.4
HbA1c measurement
1
49.5
apolipoprotein B measurement
1
41.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NPC1 like intracellular cholesterol transporter 1
VGNC:8703
463381
Macaque
NPC1 like intracellular cholesterol transporter 1
699235
Mouse
MGI:2685089
237636
Rat
RGD:1303135
432367
Horse
NPC1 like intracellular cholesterol transporter 1
VGNC:20832
100065105
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NPC1 like intracellular cholesterol transporter 1
Macaque
NPC1 like intracellular cholesterol transporter 1
Mouse
Rat
Horse
NPC1 like intracellular cholesterol transporter 1
Publication Statistics
PubMed Score 330.62
PubMed score by year
PubTator Score 178.16
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title