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Tbio
MKRN1
E3 ubiquitin-protein ligase makorin-1

Protein Summary
Description
E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. These substrates include FILIP1, p53/TP53, CDKN1A and TERT. Keeps cells alive by suppressing p53/TP53 under normal conditions, but stimulates apoptosis by repressing CDKN1A under stress conditions. Acts as a negative regulator of telomerase. Has negative and positive effects on RNA polymerase II-dependent transcription. This gene encodes a protein that belongs to a novel class of zinc finger proteins. The encoded protein functions as a transcriptional co-regulator, and as an E3 ubiquitin ligase that promotes the ubiquitination and proteasomal degradation of target proteins. The protein encoded by this gene is thought to regulate RNA polymerase II-catalyzed transcription. Substrates for this protein's E3 ubiquitin ligase activity include the capsid protein of the West Nile virus and the catalytic subunit of the telomerase ribonucleoprotein. This protein controls cell cycle arrest and ap ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000255977
  • ENSP00000255977
  • ENSG00000133606
  • ENST00000443720
  • ENSP00000416369
  • ENST00000474576
  • ENSP00000417863

Symbol
  • RNF61
  • RNF61
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
transcription factor perturbation
1
disease perturbation
0.98
transcription factor binding site profile
0.86
protein domain
0.85


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.77   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 320   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.77   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 320   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
risky sexual behaviour measurement
1
1
1
31.5
reticulocyte measurement
1
1
1
30.2
risk-taking behaviour
1
1
1
11.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
risky sexual behaviour measurement
1
31.5
reticulocyte measurement
1
30.2
risk-taking behaviour
1
11.3
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
makorin ring finger protein 1
VGNC:4428
463778
Macaque
makorin ring finger protein 1
716752
Mouse
MGI:1859353
54484
Dog
makorin ring finger protein 1
475528
Horse
makorin ring finger protein 1
100065893
Species
Name
OMA
EggNOG
Inparanoid
Chimp
makorin ring finger protein 1
Macaque
makorin ring finger protein 1
Mouse
Dog
makorin ring finger protein 1
Horse
makorin ring finger protein 1
Pathways (11)
AKT phosphorylates targets in the cytosol (R-HSA-198323)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AKT phosphorylates targets in the cytosol
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
AKT phosphorylates targets in the cytosol
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Protein-Protein Interactions (307)
1 – 10 of 307
SNRNP70
Tbio
Novelty: 0.00116631
p_int: 0.992776757
p_ni: 0.006702141
p_wrong: 0.000521102
Data Source: BioPlex
TRA2A
Tbio
Novelty: 0.04935993
p_int: 0.990565862
p_ni: 0.00101001
p_wrong: 0.008424128
Score: 0.55
Data Source: BioPlex,STRINGDB
NOP53
Tbio
Novelty: 0.00353077
p_int: 0.989073638
p_ni: 0.010436692
p_wrong: 0.00048967
Score: 0.159
Data Source: BioPlex,STRINGDB
LUC7L
Tbio
Novelty: 0.05748021
p_int: 0.98833754
p_ni: 0.011474678
p_wrong: 0.000187782
Score: 0.546
Data Source: BioPlex,STRINGDB
SNIP1
Tbio
Novelty: 0.01865867
p_int: 0.985940174
p_ni: 0.003433039
p_wrong: 0.010626787
Score: 0.521
Data Source: BioPlex,STRINGDB
RRS1
Tbio
Novelty: 0.01643671
p_int: 0.979407969
p_ni: 0.003693288
p_wrong: 0.016898743
Data Source: BioPlex
CELF3
Tbio
Novelty: 0.01495441
p_int: 0.979268814
p_ni: 0.020381264
p_wrong: 0.000349923
Score: 0.269
Data Source: BioPlex,STRINGDB
RBFOX1
Tbio
Novelty: 0.00571285
p_int: 0.979079688
p_ni: 0.002831576
p_wrong: 0.018088737
Score: 0.19
Data Source: BioPlex,STRINGDB
LUC7L2
Tdark
Novelty: 0.36989457
p_int: 0.967941277
p_ni: 0.001257402
p_wrong: 0.030801321
Score: 0.274
Data Source: BioPlex,STRINGDB
RNF130
Tdark
Family: Enzyme
Novelty: 0.26931521
Score: 0.962
Data Source: STRINGDB
Publication Statistics
PubMed Score  28.77

PubMed score by year
PubTator Score  12.35

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer