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Tchem
ASIC3
Acid-sensing ion channel 3

Protein Summary
Description
Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Generates a biphasic current with a fast inactivating and a slow sustained phase. In sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic, damaged or inflamed tissue. May be involved in hyperalgesia. May play a role in mechanoreception. Heteromeric channel assembly seems to modulate channel properties. This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, two hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene is an acid sensor and may play an important role in the detection of lasting pH changes. In addition, a heteromeric association between this member and acid-sensing ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000297512
  • ENSP00000297512
  • ENSG00000213199
  • ENST00000349064
  • ENSP00000344838
  • ENST00000357922
  • ENSP00000350600
  • ENST00000377904
  • ENSP00000367136
  • ENST00000468325
  • ENSP00000418605

Symbol
  • ACCN3
  • SLNAC1
  • TNAC1
  • ACCN3
  • TNaC1
  • DRASIC
  • SLNAC1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.88
cell type or tissue
0.65
tissue sample
0.61
cellular component
0.6
disease perturbation
0.56


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 297.77   (req: < 5)
Gene RIFs: 27   (req: <= 3)
Antibodies: 160   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 297.77   (req: >= 5)
Gene RIFs: 27   (req: > 3)
Antibodies: 160   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 37
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
acid sensing ion channel subunit 3
VGNC:4275
472627
Mouse
MGI:2159339
171209
Rat
RGD:708578
286920
Dog
acid sensing ion channel subunit 3
VGNC:38179
482801
Horse
acid sensing ion channel subunit 3
VGNC:15583
100063408
Species
Name
OMA
EggNOG
Inparanoid
Chimp
acid sensing ion channel subunit 3
Mouse
Rat
Dog
acid sensing ion channel subunit 3
Horse
acid sensing ion channel subunit 3
Pathways (4)
Ion channel transport (R-HSA-983712)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Ion channel transport
Reactome
Stimuli-sensing channels
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Ion channel transport
Stimuli-sensing channels
Transport of small molecules
Protein-Protein Interactions (42)
1 – 10 of 42
STOM
Tbio
Novelty: 0.00459891
Score: 0.969
Data Source: STRINGDB
STOML3
Tbio
Novelty: 0.0587281
Score: 0.958
Data Source: Reactome,STRINGDB
TRPV1
Tclin
Family: IC
Novelty: 0.00039493
Score: 0.826
Data Source: STRINGDB
PICK1
Tbio
Novelty: 0.0058265
Score: 0.757
Data Source: STRINGDB
NGF
Tchem
Novelty: 0.00008139
Score: 0.713
Data Source: STRINGDB
PATJ
Tbio
Novelty: 0.01420008
Score: 0.707
Data Source: STRINGDB
TRPA1
Tclin
Family: IC
Novelty: 0.00093648
Score: 0.691
Data Source: STRINGDB
P2RX3
Tchem
Family: IC
Novelty: 0.00203167
Score: 0.678
Data Source: STRINGDB
LIN7B
Tbio
Novelty: 0.12689192
Score: 0.612
Data Source: STRINGDB
P2RX5
Tchem
Family: IC
Novelty: 0.01591178
Score: 0.602
Data Source: STRINGDB
Publication Statistics
PubMed Score  297.77

PubMed score by year
PubTator Score  84.35

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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