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Tbio
SRP68
Signal recognition particle subunit SRP68

Protein Summary
Description
Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP68 binds the 7S RNA, SRP72 binds to this complex subsequently. This ribonucleoprotein complex might interact directly with the docking protein in the ER membrane and possibly participate in the elongation arrest function. This gene encodes a subunit of the signal recognition particle (SRP). The SRP is a ribonucleoprotein complex that transports secreted and membrane proteins to the endoplasmic reticulum for processing. The complex includes a 7S RNA and six protein subunits. The encoded protein is the 68kDa component of the SRP, and forms a heterodimer with the 72kDa subunit that is required for SRP function. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and three pseudogenes of this gene are located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, May 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000307877
  • ENSP00000312066
  • ENSG00000167881
  • ENST00000539137
  • ENSP00000446136
  • ENST00000602720
  • ENSP00000473613
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.87
cellular component
0.78
small molecule perturbation
0.75
hub protein
0.71
kinase perturbation
0.66


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IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.4   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 122   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.4   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 122   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
signal recognition particle 68
VGNC:9654
738851
Macaque
signal recognition particle 68
705568
Mouse
MGI:1917447
217337
Rat
RGD:1305376
363707
Dog
signal recognition particle 68
VGNC:46808
403952
Species
Name
OMA
EggNOG
Inparanoid
Chimp
signal recognition particle 68
Macaque
signal recognition particle 68
Mouse
Rat
Dog
signal recognition particle 68
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9UHB9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (4)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
SRP-dependent cotranslational protein targeting to membrane
Reactome
Translation
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
SRP-dependent cotranslational protein targeting to membrane
Translation
Gene Ontology Terms (14)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
CAFA
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (229)
1 – 10 of 229
SRP54
Tbio
Novelty: 0.00535567
p_int: 0.999999999
p_ni: 1e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
SRP19
Tbio
Novelty: 0.01831843
p_int: 0.999998583
p_ni: 1.57e-7
p_wrong: 0.000001261
Score: 0.999
Data Source: BioPlex,STRINGDB
SRP9
Tbio
Novelty: 0.02243103
p_int: 0.999998249
p_ni: 0.000001751
Score: 0.999
Data Source: BioPlex,STRINGDB
SRP72
Tbio
Novelty: 0.03264445
p_int: 0.999987647
p_ni: 0.000012353
Score: 0.999
Data Source: BioPlex,STRINGDB
FZR1
Tbio
Novelty: 0.01599606
p_int: 0.997377395
p_ni: 0.0026226
p_wrong: 5e-9
Data Source: BioPlex
GIMAP8
Tbio
Family: Enzyme
Novelty: 0.13237721
p_int: 0.995248215
p_ni: 0.004751785
Score: 0.619
Data Source: BioPlex,STRINGDB
RBM34
Tdark
Novelty: 0.58131282
p_int: 0.988320047
p_ni: 0.011679953
Score: 0.432
Data Source: BioPlex,STRINGDB
SRP14
Tbio
Novelty: 0.03745351
p_int: 0.976389171
p_ni: 0.023610829
Score: 0.999
Data Source: BioPlex,STRINGDB
EPB41L2
Tbio
Novelty: 0.0311733
p_int: 0.975395642
p_ni: 0.024604358
Score: 0.209
Data Source: BioPlex,STRINGDB
AXDND1
Tdark
Novelty: 2.95591966
p_int: 0.974499395
p_ni: 0.025500605
Score: 0.303
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  21.40

PubMed score by year
PubTator Score  14.96

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer