Tbio SRP68 Signal recognition particle subunit SRP68

Protein Summary

Description

Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP68 binds the 7S RNA, SRP72 binds to this complex subsequently. This ribonucleoprotein complex might interact directly with the docking protein in the ER membrane and possibly participate in the elongation arrest function. This gene encodes a subunit of the signal recognition particle (SRP). The SRP is a ribonucleoprotein complex that transports secreted and membrane proteins to the endoplasmic reticulum for processing. The complex includes a 7S RNA and six protein subunits. The encoded protein is the 68kDa component of the SRP, and forms a heterodimer with the 72kDa subunit that is required for SRP function. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and three pseudogenes of this gene are located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, May 2012]

Uniprot Accession IDs

• Q9UHB9
• B3KUU5
• B3KWY7
• G3V1U4
• Q8NCJ4
• Q8WUK2
• SRP68

Gene Name

• SRP68

Ensembl ID

• ENST00000307877
• ENSP00000312066
• ENSG00000167881
• ENST00000539137
• ENSP00000446136
• ENST00000602720
• ENSP00000473613

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.87
cellular component	0.78
small molecule perturbation	0.75
hub protein	0.71
kinase perturbation	0.66

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Signal Recognition Particle Subunit Srp68

DTO Classes

Protein / Nucleic Acid Binding / Signal Recognition Particle Subunit Srp68

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.43   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 122   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.43   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 122   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0