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Tbio
AFF4
AF4/FMR2 family member 4

Protein Summary
Description
Key component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. In the SEC complex, AFF4 acts as a central scaffold that recruits other factors through direct interactions with ELL proteins (ELL, ELL2 or ELL3) and the P-TEFb complex. In case of infection by HIV-1 virus, the SEC complex is recruited by the viral Tat protein to stimulate viral gene expression. The protein encoded by this gene belongs to the AF4 family of transcription factors involved in leukemia. It is a component of the positive transcription elongation factor b (P-TEFb) complex. A chromosomal translocation involving this gene and MLL gene on chromosome 11 is found in infant acute lymphoblastic leukemia with ins(5;11)(q31;q31q23). [provided by RefSeq, Oct 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265343
  • ENSP00000265343
  • ENSG00000072364
  • ENST00000378595
  • ENSP00000367858

Symbol
  • AF5Q31
  • MCEF
  • MCEF
  • CHOPS
  • AF5Q31
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
0.99
transcription factor binding site profile
0.87
transcription factor perturbation
0.84
cell type or tissue
0.77
microRNA
0.77


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.09   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 228   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.09   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 228   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (121)
ELL3
Tbio
Family:  Enzyme
Novelty:  0.18245631
p_int:  1
Score:  0.932
Data Source:  BioPlex,STRINGDB
PIP4K2A
Tbio
Family:  Kinase
Novelty:  0.01130885
p_int:  0.999999818
p_ni:  1.81e-7
p_wrong:  1e-9
Score:  0.232
Data Source:  BioPlex,STRINGDB
ELL2
Tbio
Family:  Enzyme
Novelty:  0.040736
p_int:  0.999999783
p_ni:  2.17e-7
Score:  0.996
Data Source:  BioPlex,STRINGDB
EAF1
Tbio
Novelty:  0.81120425
p_int:  0.999999622
p_ni:  3.78e-7
Score:  0.979
Data Source:  BioPlex,STRINGDB
CDK9
Tchem
Family:  Kinase
Novelty:  0.00210218
p_int:  0.999999437
p_ni:  5.63e-7
Score:  0.999
Data Source:  BioPlex,STRINGDB
CAMKV
Tbio
Family:  Kinase
Novelty:  0.17794181
p_int:  0.999997874
p_ni:  0.000002126
Data Source:  BioPlex
EAF2
Tbio
Family:  TF
Novelty:  0.08392419
p_int:  0.999996827
p_ni:  0.000003074
p_wrong:  9.9e-8
Score:  0.987
Data Source:  BioPlex,STRINGDB
EPB41L1
Tbio
Novelty:  0.02937451
p_int:  0.999991606
p_ni:  0.000008394
Data Source:  BioPlex
CCNT2
Tbio
Novelty:  0.04593314
p_int:  0.999987486
p_ni:  0.000012514
Score:  0.996
Data Source:  BioPlex,STRINGDB
ELL
Tbio
Family:  Enzyme
Novelty:  0.00424352
p_int:  0.99998586
p_ni:  0.00001414
Score:  0.996
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Formation of RNA Pol II elongation complex (R-HSA-112382)

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Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Formation of RNA Pol II elongation complex
Reactome
Gene expression (Transcription)
Reactome
RNA Polymerase II Pre-transcription Events
Reactome
RNA Polymerase II Transcription
Reactome
RNA Polymerase II Transcription Elongation
Name
Explore in Pharos
Explore in Source
Formation of RNA Pol II elongation complex
Gene expression (Transcription)
RNA Polymerase II Pre-transcription Events
RNA Polymerase II Transcription
RNA Polymerase II Transcription Elongation
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
IGF-1 measurement
1
2
2
80
monocyte count
1
1
1
78.6
glomerular filtration rate
3
2
3
76.7
waist-hip ratio
3
4
4
75.4
waist circumference
1
3
3
73.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
IGF-1 measurement
2
80
monocyte count
1
78.6
glomerular filtration rate
3
76.7
waist-hip ratio
4
75.4
waist circumference
3
73.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
AF4/FMR2 family member 4
VGNC:3897
107974861
Macaque
AF4/FMR2 family member 4
709137
Mouse
MGI:2136171
93736
Rat
RGD:1311694
303132
Dog
AF4/FMR2 family member 4
VGNC:37688
474678
Species
Name
OMA
EggNOG
Inparanoid
Chimp
AF4/FMR2 family member 4
Macaque
AF4/FMR2 family member 4
Mouse
Rat
Dog
AF4/FMR2 family member 4
Publication Statistics
PubMed Score 56.09
PubMed score by year
PubTator Score 22.49
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title