Tbio LIMA1 LIM domain and actin-binding protein 1

Protein Summary

Description

Actin-binding protein involved in actin cytoskeleton regulation and dynamics. Increases the number and size of actin stress fibers and inhibits membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments, delays filament nucleation and reduces formation of branched filaments (PubMed:12566430). Plays a role in cholesterol homeostasis. Influences plasma cholesterol levels through regulation of intestinal cholesterol absorption. May act as a scaffold protein by regulating NPC1L1 transportation, an essential protein for cholesterol absorption, to the plasma membrane by recruiting MYO5B to NPC1L1, and thus facilitates cholesterol uptake (By similarity). This gene encodes a cytoskeleton-associated protein that inhibits actin filament depolymerization and cross-links filaments in bundles. It is downregulated in some cancer cell lines. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, and expression of some of the variants maybe independently regulated. [provided by RefSeq, Aug 2011]

Uniprot Accession IDs

• Q9UHB6
• B2RB09
• Q2TAN7
• Q59FE8
• Q9BVF2
• Q9H8J1
• Q9HBN5
• Q9NX96
• Q9NXC3
• Q9NXU6
• Q9P0H8
• Q9UHB5

Gene Name

• LIMA1

Ensembl ID

• ENST00000341247
• ENSP00000340184
• ENSG00000050405
• ENST00000394943
• ENSP00000378400
• ENST00000547825
• ENSP00000448706
• ENST00000552783
• ENSP00000448779
• ENST00000552823
• ENSP00000450266

Symbol

• EPLIN
• SREBP3
• EPLIN
• LDLCQ8
• SREBP3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	1
interacting protein	0.96
disease perturbation	0.93
kinase perturbation	0.93
PubMedID	0.92

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Lim Domain And Actin-binding Protein 1

Protein / Nucleic Acid Binding / Nuclease / Lim Domain And Actin-binding Protein 1

Protein / Cytoskeletal Protein / Actin Family Cytoskeletal Protein / Lim Domain And Actin-binding Protein 1

DTO Classes

Protein / Enzyme / Nuclease / Lim Domain And Actin-binding Protein 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.75   (req: < 5)

Gene RIFs: 23   (req: <= 3)

Antibodies: 268   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.75   (req: >= 5)

Gene RIFs: 23   (req: > 3)

Antibodies: 268   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0