NDOR1
NADPH-dependent diflavin oxidoreductase 1
Protein Summary
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins (By similarity). Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis. Transfers electrons from NADPH to the Fe/S cluster of CIAPIN1. This gene encodes an NADPH-dependent diflavin reductase that contains both flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD) binding domains. The encoded protein catalyzes the transfer of electrons from NADPH through FAD and FMN cofactors to potential redox partners. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012]
- ENST00000344894
- ENSP00000343344
- ENSG00000188566
- ENST00000371521
- ENSP00000360576
- ENST00000427047
- ENSP00000394309
- ENST00000458322
- ENSP00000389905
- NR1
- NR1
- CIAE1
- bA350O14.9
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 1 | ||
molecular function | 0.91 | ||
histone modification site profile | 0.74 | ||
gene perturbation | 0.67 | ||
cell type or tissue | 0.62 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 8.99 (req: < 5)
Gene RIFs: 4 (req: <= 3)
Antibodies: 203 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 8.99 (req: >= 5)
Gene RIFs: 4 (req: > 3)
Antibodies: 203 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0