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Tbio
LAMTOR3
Ragulator complex protein LAMTOR3

Protein Summary
Description
As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2. This gene encodes a scaffold protein that functions in the extracellular signal-regulated kinase (ERK) cascade. The protein is localized to late endosomes by the mitogen-activated protein-binding protein-interacting protein, and binds specifically to MAP kinase kinase MAP2K1/MEK1, MAP kinase MAPK3/ERK1, and MAP kinase MAPK1/ERK2. Studies of the orthologous gene in mouse indicate that it re ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000226522
  • ENSP00000226522
  • ENSG00000109270
  • ENST00000499666
  • ENSP00000424183

Symbol
  • MAP2K1IP1
  • MAPKSP1
  • MP1
  • MAPBP
  • MAPKSP1
  • PRO0633
  • MAP2K1IP1
  • Ragulator3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.9
kinase perturbation
0.81
histone modification site profile
0.77
cellular component
0.75
interacting protein
0.75


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.7   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 207   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.7   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 207   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
1
1
13.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
13.2
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
late endosomal/lysosomal adaptor, MAPK and MTOR activator 3
VGNC:8265
461399
Mouse
MGI:1929467
56692
Rat
RGD:1307133
362045
Dog
late endosomal/lysosomal adaptor, MAPK and MTOR activator 3
VGNC:42578
478492
Horse
late endosomal/lysosomal adaptor, MAPK and MTOR activator 3
VGNC:19576
100629409
Species
Name
OMA
EggNOG
Inparanoid
Chimp
late endosomal/lysosomal adaptor, MAPK and MTOR activator 3
Mouse
Rat
Dog
late endosomal/lysosomal adaptor, MAPK and MTOR activator 3
Horse
late endosomal/lysosomal adaptor, MAPK and MTOR activator 3
Protein Structure (10 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9UHA4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 10
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (195)
Autophagy (R-HSA-9612973)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 27
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Autophagy
Reactome
Cellular responses to external stimuli
Reactome
Cytokine Signaling in Immune system
Reactome
Energy dependent regulation of mTOR by LKB1-AMPK
Reactome
FLT3 Signaling
Name
Explore in Pharos
Explore in Source
Autophagy
Cellular responses to external stimuli
Cytokine Signaling in Immune system
Energy dependent regulation of mTOR by LKB1-AMPK
FLT3 Signaling
Gene Ontology Terms (17)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (206)
1 – 10 of 206
RRAGD
Tbio
Novelty: 0.04742375
p_int: 0.999999863
p_ni: 1.35e-7
p_wrong: 1e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
RRAGC
Tbio
Novelty: 0.01462756
p_int: 0.999996483
p_ni: 0.000003517
Score: 0.999
Data Source: BioPlex,STRINGDB
SLC38A9
Tbio
Family: Transporter
Novelty: 0.0879703
p_int: 0.999984374
p_ni: 0.000015618
p_wrong: 8e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
RRAGB
Tbio
Novelty: 0.02279777
p_int: 0.999967103
p_ni: 0.000032897
p_wrong: 1e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
RPTOR
Tbio
Novelty: 0.00119147
p_int: 0.998995626
p_ni: 0.001004374
Score: 0.999
Data Source: BioPlex,STRINGDB
LAMTOR1
Tbio
Novelty: 0.04952213
p_int: 0.996859273
p_ni: 0.003140727
p_wrong: 1e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
BORCS6
Tdark
Novelty: 0.83789033
p_int: 0.995518212
p_ni: 0.004481785
p_wrong: 3e-9
Score: 0.497
Data Source: BioPlex,STRINGDB
LAMTOR2
Tbio
Novelty: 0.05210182
p_int: 0.993364653
p_ni: 0.006635347
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
BORCS5
Tdark
Novelty: 0.59333419
p_int: 0.992250977
p_ni: 0.00774902
p_wrong: 2e-9
Data Source: BioPlex
LAMTOR4
Tdark
Novelty: 0.24218646
p_int: 0.979720436
p_ni: 0.01975744
p_wrong: 0.000522124
Score: 0.999
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  14.70

PubMed score by year
PubTator Score  57.62

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer