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Tbio
SUN2
SUN domain-containing protein 2

Protein Summary
Description
As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Required for nuclear migration in retinal photoreceptor progenitors implicating association with cytoplasmic dynein-dynactin and kinesin motor complexes, and probably B-type lamins; SUN1 and SUN2 seem to act redundantly. ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000405018
  • ENSP00000385616
  • ENSG00000100242
  • ENST00000405510
  • ENSP00000385740
  • ENST00000406622
  • ENSP00000383992

Symbol
  • FRIGG
  • KIAA0668
  • RAB5IP
  • UNC84B
  • UNC84B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.97
kinase perturbation
0.91
cellular component
0.86
interacting protein
0.82
transcription factor perturbation
0.8


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 75.6   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 170   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 75.6   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 170   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
1
2
89.2
mathematical ability
3
2
3
88.9
prostate carcinoma
1
1
0
1.2
63
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
89.2
mathematical ability
3
88.9
prostate carcinoma
0
1.2
63
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Sad1 and UNC84 domain containing 2
VGNC:6000
458837
Macaque
Sad1 and UNC84 domain containing 2
704914
Mouse
MGI:2443011
223697
Rat
RGD:1563141
315135
Dog
Sad1 and UNC84 domain containing 2
VGNC:46985
481250
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Sad1 and UNC84 domain containing 2
Macaque
Sad1 and UNC84 domain containing 2
Mouse
Rat
Dog
Sad1 and UNC84 domain containing 2
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9UH99-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (4)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Meiosis
Reactome
Meiotic synapsis
Reactome
Reproduction
Name
Explore in Pharos
Explore in Source
Cell Cycle
Meiosis
Meiotic synapsis
Reproduction
Gene Ontology Terms (21)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
UniProtKB
Protein-Protein Interactions (147)
1 – 10 of 147
GOLGA7B
Tdark
Novelty: 1.09326611
p_int: 0.999998657
p_ni: 0.000001343
Score: 0.47
Data Source: BioPlex,STRINGDB
FBXW11
Tbio
Novelty: 0.0715377
p_int: 0.999996736
p_ni: 0.000003264
Score: 0.297
Data Source: BioPlex,STRINGDB
FKBP14
Tbio
Family: Enzyme
Novelty: 0.02742616
p_int: 0.999995798
p_ni: 0.000004202
Data Source: BioPlex
BTRC
Tbio
Novelty: 0.00293475
p_int: 0.999994535
p_ni: 0.000005465
Score: 0.556
Data Source: BioPlex,STRINGDB
DHRS4
Tbio
Family: Enzyme
Novelty: 0.02992279
p_int: 0.999994094
p_ni: 0.000005906
Data Source: BioPlex
RAB5A
Tbio
Family: Enzyme
Novelty: 0.00111347
p_int: 0.99998017
p_ni: 0.00001983
Score: 0.625
Data Source: BioPlex,STRINGDB
COPS7B
Tbio
Novelty: 0.63421506
p_int: 0.999968221
p_ni: 0.000031779
Data Source: BioPlex
RAB5C
Tbio
Family: Enzyme
Novelty: 0.02952779
p_int: 0.999856493
p_ni: 0.000143507
Score: 0.588
Data Source: BioPlex,STRINGDB
PIP
Tbio
Novelty: 0.00208509
p_int: 0.999713186
p_ni: 0.000286814
Data Source: BioPlex
CSGALNACT2
Tbio
Family: Enzyme
Novelty: 0.0770692
p_int: 0.99880839
p_ni: 0.00119161
Score: 0.159
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  75.60

PubMed score by year
PubTator Score  42.03

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer