Protein Summary
Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MAD1, MAD4, MNT, WBSCR14 and MLXIP which recognizes the core sequence 5'-CACGTG-3'. The TCFL4-MAD1, TCFL4-MAD4, TCFL4-WBSCR14 complexes are transcriptional repressors. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation. The product of this gene belongs to the family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors. These factors form heterodimers with Mad proteins and play a role in proliferation, determination and differentiation. This gene product may act to diversify Mad family function by its restricted association with a subset of the Mad family of transcriptional repressors, namely, Mad1 and Mad4. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
- ENST00000246912
- ENSP00000246912
- ENSG00000108788
- ENST00000346833
- ENSP00000320913
- ENST00000435881
- ENSP00000416627
- BHLHD13
- TCFL4
- TF4
- MAD7
- MXD7
- TCFL4
- bHLHd13
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
disease perturbation | 1 | ||
kinase perturbation | 1 | ||
molecular function | 0.79 | ||
transcription factor | 0.65 | ||
transcription factor binding site profile | 0.65 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 172.74 (req: < 5)
Gene RIFs: 6 (req: <= 3)
Antibodies: 315 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 172.74 (req: >= 5)
Gene RIFs: 6 (req: > 3)
Antibodies: 315 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 13
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 7
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
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Approved Drugs (0)
Active Ligands (7)
Protein-Protein Interactions (54)
MLXIPL
Family: TF
Novelty: 0.00357389
p_int: 1
Score: 0.979
Data Source: BioPlex,Reactome,STRINGDB
CSPG5
Novelty: 0.01629685
p_int: 0.999999694
p_ni: 2.53e-7
p_wrong: 5.3e-8
Score: 0.219
Data Source: BioPlex,STRINGDB
CSNK2A2
Family: Kinase
Novelty: 0.00231447
p_int: 0.999291709
p_ni: 0.000708291
Data Source: BioPlex
BACH1
Family: TF
Novelty: 0.04011328
p_int: 0.998548397
p_ni: 0.00145156
p_wrong: 4.3e-8
Data Source: BioPlex
CSNK2A1
Family: Kinase
Novelty: 0.00187855
p_int: 0.998525721
p_ni: 0.001474279
Data Source: BioPlex
SNX1
Novelty: 0.01267973
p_int: 0.996117122
p_ni: 0.003882441
p_wrong: 4.37e-7
Score: 0.326
Data Source: BioPlex,STRINGDB
AMPD2
Family: Enzyme
Novelty: 0.01510718
p_int: 0.946201168
p_ni: 0.053798763
p_wrong: 6.9e-8
Score: 0.163
Data Source: BioPlex,STRINGDB
MGA
Family: TF
Novelty: 0.08965274
p_int: 0.934813761
p_ni: 0.065186238
p_wrong: 1e-9
Score: 0.33
Data Source: BioPlex,STRINGDB
SNX5
Novelty: 0.04075649
p_int: 0.818593837
p_ni: 0.181406161
p_wrong: 2e-9
Score: 0.544
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (1)
Upstream (1)
1 – 1 of 1
Pathways (6)
Reactome (3)
KEGG (2)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | ChREBP activates metabolic gene expression | ||||
Reactome | Integration of energy metabolism | ||||
Reactome | Metabolism | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
ChREBP activates metabolic gene expression | ||||
Integration of energy metabolism | ||||
Metabolism | ||||
Viral Interactions (0)
Gene Ontology Terms (18)
Functions (8)
Components (5)
Processes (5)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | NTNU_SB | |||
Inferred from Direct Assay (IDA) | NTNU_SB | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Sequence Alignment (ISA) | NTNU_SB | |||
Disease Associations ()
GWAS Traits (18)
Items per page:
1 – 5 of 18
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
4 | 4 | 2 | 1 | 91.4 | |||||
waist-hip ratio | 3 | 6 | 6 | 82 | |||||
BMI-adjusted waist-hip ratio | 1 | 4 | 4 | 76.4 | |||||
sex hormone-binding globulin measurement | 4 | 2 | 4 | 75.4 | |||||
triglyceride measurement | 3 | 2 | 3 | 68.3 | |||||
Items per page:
1 – 5 of 18
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
2 | 1 | 91.4 | |||||
waist-hip ratio | 6 | 82 | |||||
BMI-adjusted waist-hip ratio | 4 | 76.4 | |||||
sex hormone-binding globulin measurement | 4 | 75.4 | |||||
triglyceride measurement | 3 | 68.3 | |||||
Find similar targets by:
IDG Resources
Orthologs (15)
1 – 5 of 15
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | MLX, MAX dimerization protein | VGNC:9460 | 454691 | |||||
Macaque | MLX, MAX dimerization protein | 710570 | ||||||
Mouse | MGI:108398 | 21428 | ||||||
Rat | RGD:1308590 | 360631 | ||||||
Dog | MLX, MAX dimerization protein | VGNC:43267 | 607668 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | MLX, MAX dimerization protein | |||||
Macaque | MLX, MAX dimerization protein | |||||
Mouse | ||||||
Rat | ||||||
Dog | MLX, MAX dimerization protein | |||||
Publication Statistics
PubMed Score 172.74
PubMed score by year
PubTator Score 85.37
PubTator score by year
Related Publications
Text Mined References (24)
GeneRif Annotations (6)
Items per page:
0 of 0
PMID | Year | Title |
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