Tchem MLX Max-like protein X

Protein Summary

Description

Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MAD1, MAD4, MNT, WBSCR14 and MLXIP which recognizes the core sequence 5'-CACGTG-3'. The TCFL4-MAD1, TCFL4-MAD4, TCFL4-WBSCR14 complexes are transcriptional repressors. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation. The product of this gene belongs to the family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors. These factors form heterodimers with Mad proteins and play a role in proliferation, determination and differentiation. This gene product may act to diversify Mad family function by its restricted association with a subset of the Mad family of transcriptional repressors, namely, Mad1 and Mad4. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9UH92
• A8K2J3
• B2RAV8
• B2RD73
• Q53XM6
• Q96FL2
• Q9H2V0
• Q9H2V1
• Q9H2V2
• Q9NXN3

Gene Name

• MLX

Ensembl ID

• ENST00000246912
• ENSP00000246912
• ENSG00000108788
• ENST00000346833
• ENSP00000320913
• ENST00000435881
• ENSP00000416627

Symbol

• BHLHD13
• TCFL4
• TF4
• MAD7
• MXD7
• TCFL4
• bHLHd13

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
kinase perturbation	1
molecular function	0.79
transcription factor	0.65
transcription factor binding site profile	0.65

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 172.74   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 315   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 172.74   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 315   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 7

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (7)

Explore Active Ligands

1 – 7 of 7

GDC-0152

MLXTchem TF

pKi : 7.8

CHEMBL2063863

MLXTchem TF

pKi : 7.52

CHEMBL2063866

MLXTchem TF

pKi : 7.16

CHEMBL2063862

MLXTchem TF

pKi : 7.52

CHEMBL2063867

MLXTchem TF

pKi : 7.05

CHEMBL2063865

MLXTchem TF

pKi : 7.1

CHEMBL2063864

MLXTchem TF

pKi : 6.34

Protein-Protein Interactions (54)

Explore Interacting Targets

1 – 10 of 54

• See Interactions on String-DB

MLXIPL

Tbio

Family:  TF

Novelty:  0.00357389

p_int:  1

Score:  0.979

Data Source:  BioPlex,Reactome,STRINGDB

MLXIP

Tbio

Family:  TF

Novelty:  0.04454634

p_int:  1

Score:  0.96

Data Source:  BioPlex,STRINGDB

CSPG5

Tbio

Novelty:  0.01629685

p_int:  0.999999694

p_ni:  2.53e-7

p_wrong:  5.3e-8

Score:  0.219

Data Source:  BioPlex,STRINGDB

CSNK2A2

Tchem

Family:  Kinase

Novelty:  0.00231447

p_int:  0.999291709

p_ni:  0.000708291

Data Source:  BioPlex

BACH1

Tbio

Family:  TF

Novelty:  0.04011328

p_int:  0.998548397

p_ni:  0.00145156

p_wrong:  4.3e-8

Data Source:  BioPlex

CSNK2A1

Tchem

Family:  Kinase

Novelty:  0.00187855

p_int:  0.998525721

p_ni:  0.001474279

Data Source:  BioPlex

SNX1

Tbio

Novelty:  0.01267973

p_int:  0.996117122

p_ni:  0.003882441

p_wrong:  4.37e-7

Score:  0.326

Data Source:  BioPlex,STRINGDB

AMPD2

Tchem

Family:  Enzyme

Novelty:  0.01510718

p_int:  0.946201168

p_ni:  0.053798763

p_wrong:  6.9e-8

Score:  0.163

Data Source:  BioPlex,STRINGDB

MGA

Tbio

Family:  TF

Novelty:  0.08965274

p_int:  0.934813761

p_ni:  0.065186238

p_wrong:  1e-9

Score:  0.33

Data Source:  BioPlex,STRINGDB

SNX5

Tbio

Novelty:  0.04075649

p_int:  0.818593837

p_ni:  0.181406161

p_wrong:  2e-9

Score:  0.544

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets (1)

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Upstream (1)

1 – 1 of 1

INSR

Tclin

Family:  Kinase

KEGG Distance:  2

Common Pathways:  2

1: Insulin resistance

2: Non-alcoholic fatty liver disease (NAFLD)

Pathways (6)

Reactome (3)

KEGG (2)

WikiPathways (1)

ChREBP activates metabolic gene expression (R-HSA-163765)

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1 – 3 of 3

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	ChREBP activates metabolic gene expression	8 targets	R-HSA-163765
Reactome	Integration of energy metabolism	111 targets	R-HSA-163685
Reactome	Metabolism	2112 targets	R-HSA-1430728

Name	Explore in Pharos	Explore in Source
ChREBP activates metabolic gene expression	8 targets	R-HSA-163765
Integration of energy metabolism	111 targets	R-HSA-163685
Metabolism	2112 targets	R-HSA-1430728

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (18)

Functions (8)

Components (5)

Processes (5)

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10

1 – 8 of 8

GO Term	Evidence	Assigned by
DNA binding	Inferred from Direct Assay (IDA)	BHF-UCL
DNA-binding transcription repressor activity, RNA polymerase II-specific	Inferred from Direct Assay (IDA)	NTNU_SB
RNA polymerase II regulatory region sequence-specific DNA binding	Inferred from Direct Assay (IDA)	NTNU_SB
protein heterodimerization activity	Inferred from Physical Interaction (IPI)	BHF-UCL
protein homodimerization activity	Inferred from Physical Interaction (IPI)	BHF-UCL
transcription factor binding	Inferred from Physical Interaction (IPI)	BHF-UCL
DNA-binding transcription factor activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
DNA-binding transcription factor activity, RNA polymerase II-specific	Inferred from Sequence Alignment (ISA)	NTNU_SB

Disease Associations ()

No disease associations found

GWAS Traits (18)

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5

1 – 5 of 18

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
type II diabetes mellitus	EFO_0001360	4	4	2	1	91.4
waist-hip ratio	EFO_0004343	3	6	6		82
BMI-adjusted waist-hip ratio	EFO_0007788	1	4	4		76.4
sex hormone-binding globulin measurement	EFO_0004696	4	2	4		75.4
triglyceride measurement	EFO_0004530	3	2	3		68.3

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1 – 5 of 18

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
type II diabetes mellitus	EFO_0001360	2	1	91.4
waist-hip ratio	EFO_0004343	6		82
BMI-adjusted waist-hip ratio	EFO_0007788	4		76.4
sex hormone-binding globulin measurement	EFO_0004696	4		75.4
triglyceride measurement	EFO_0004530	3		68.3

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UniProt Keyword Find Similar Targets

No Header	No Header
Activator
Alternative splicing
Complete proteome
Cytoplasm
DNA-binding
Nucleus
Phosphoprotein
Polymorphism
Reference proteome
Repressor

GWAS Trait Find Similar Targets

No Header	No Header
apolipoprotein A 1 measurement
BMI-adjusted waist-hip ratio
C-reactive protein measurement
cataract
Drugs used in diabetes use measurement
Eczema
heel bone mineral density
high density lipoprotein cholesterol measurement
leukocyte count
metabolic syndrome

MGI Phenotype Find Similar Targets

No Header	No Header
adipose tissue phenotype
behavior/neurological phenotype
reproductive system phenotype
skeleton phenotype

IDG Resources

No IDG generated resources found

Orthologs (15)

1 – 5 of 15

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	MLX, MAX dimerization protein	VGNC:9460	454691
Macaque	MLX, MAX dimerization protein		710570
Mouse	MAX-like protein X	MGI:108398	21428
Rat	MLX, MAX dimerization protein	RGD:1308590	360631
Dog	MLX, MAX dimerization protein	VGNC:43267	607668

Species	Name	OMA	EggNOG	Inparanoid
Chimp	MLX, MAX dimerization protein
Macaque	MLX, MAX dimerization protein
Mouse	MAX-like protein X
Rat	MLX, MAX dimerization protein
Dog	MLX, MAX dimerization protein

Publication Statistics

PubMed Score 172.74

PubMed score by year

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PubTator Score 85.37

PubTator score by year

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Related Publications

Text Mined References (24)

GeneRif Annotations (6)

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PMID	Year	Title