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Tchem
MLX
Max-like protein X

Protein Summary
Description
Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MAD1, MAD4, MNT, WBSCR14 and MLXIP which recognizes the core sequence 5'-CACGTG-3'. The TCFL4-MAD1, TCFL4-MAD4, TCFL4-WBSCR14 complexes are transcriptional repressors. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation. The product of this gene belongs to the family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors. These factors form heterodimers with Mad proteins and play a role in proliferation, determination and differentiation. This gene product may act to diversify Mad family function by its restricted association with a subset of the Mad family of transcriptional repressors, namely, Mad1 and Mad4. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000246912
  • ENSP00000246912
  • ENSG00000108788
  • ENST00000346833
  • ENSP00000320913
  • ENST00000435881
  • ENSP00000416627

Symbol
  • BHLHD13
  • TCFL4
  • TF4
  • MAD7
  • MXD7
  • TCFL4
  • bHLHd13
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
kinase perturbation
1
molecular function
0.79
transcription factor
0.65
transcription factor binding site profile
0.65


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 172.74   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 315   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 172.74   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 315   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 7
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (54)
MLXIPL
Tbio
Family:  TF
Novelty:  0.00357389
p_int:  1
Score:  0.979
Data Source:  BioPlex,Reactome,STRINGDB
MLXIP
Tbio
Family:  TF
Novelty:  0.04454634
p_int:  1
Score:  0.96
Data Source:  BioPlex,STRINGDB
CSPG5
Tbio
Novelty:  0.01629685
p_int:  0.999999694
p_ni:  2.53e-7
p_wrong:  5.3e-8
Score:  0.219
Data Source:  BioPlex,STRINGDB
CSNK2A2
Tchem
Family:  Kinase
Novelty:  0.00231447
p_int:  0.999291709
p_ni:  0.000708291
Data Source:  BioPlex
BACH1
Tbio
Family:  TF
Novelty:  0.04011328
p_int:  0.998548397
p_ni:  0.00145156
p_wrong:  4.3e-8
Data Source:  BioPlex
CSNK2A1
Tchem
Family:  Kinase
Novelty:  0.00187855
p_int:  0.998525721
p_ni:  0.001474279
Data Source:  BioPlex
SNX1
Tbio
Novelty:  0.01267973
p_int:  0.996117122
p_ni:  0.003882441
p_wrong:  4.37e-7
Score:  0.326
Data Source:  BioPlex,STRINGDB
AMPD2
Tchem
Family:  Enzyme
Novelty:  0.01510718
p_int:  0.946201168
p_ni:  0.053798763
p_wrong:  6.9e-8
Score:  0.163
Data Source:  BioPlex,STRINGDB
MGA
Tbio
Family:  TF
Novelty:  0.08965274
p_int:  0.934813761
p_ni:  0.065186238
p_wrong:  1e-9
Score:  0.33
Data Source:  BioPlex,STRINGDB
SNX5
Tbio
Novelty:  0.04075649
p_int:  0.818593837
p_ni:  0.181406161
p_wrong:  2e-9
Score:  0.544
Data Source:  BioPlex,STRINGDB
Pathways (6)
ChREBP activates metabolic gene expression (R-HSA-163765)

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1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ChREBP activates metabolic gene expression
Reactome
Integration of energy metabolism
Reactome
Metabolism
Name
Explore in Pharos
Explore in Source
ChREBP activates metabolic gene expression
Integration of energy metabolism
Metabolism
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (18)
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Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Disease Associations ()
No disease associations found
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
4
2
1
91.4
waist-hip ratio
3
6
6
82
BMI-adjusted waist-hip ratio
1
4
4
76.4
sex hormone-binding globulin measurement
4
2
4
75.4
triglyceride measurement
3
2
3
68.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1
91.4
waist-hip ratio
6
82
BMI-adjusted waist-hip ratio
4
76.4
sex hormone-binding globulin measurement
4
75.4
triglyceride measurement
3
68.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
MLX, MAX dimerization protein
VGNC:9460
454691
Macaque
MLX, MAX dimerization protein
710570
Mouse
MGI:108398
21428
Rat
RGD:1308590
360631
Dog
MLX, MAX dimerization protein
VGNC:43267
607668
Species
Name
OMA
EggNOG
Inparanoid
Chimp
MLX, MAX dimerization protein
Macaque
MLX, MAX dimerization protein
Mouse
Rat
Dog
MLX, MAX dimerization protein
Publication Statistics
PubMed Score 172.74
PubMed score by year
PubTator Score 85.37
PubTator score by year
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Related Publications
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PMID
Year
Title