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Tbio
KLHL3
Kelch-like protein 3

Protein Summary
Description
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of ion transport in the distal nephron (PubMed:14528312, PubMed:22406640, PubMed:23387299, PubMed:23453970, PubMed:23576762, PubMed:23665031). The BCR(KLHL3) complex acts by mediating ubiquitination of WNK4, an inhibitor of potassium channel KCNJ1, leading to WNK4 degradation (PubMed:23387299, PubMed:23453970, PubMed:23576762, PubMed:23665031). The BCR(KLHL3) complex also mediates ubiquitination and degradation of CLDN8, a tight-junction protein required for paracellular chloride transport in the kidney (By similarity). This gene is ubiquitously expressed and encodes a full-length protein which has an N-terminal BTB domain followed by a BACK domain and six kelch-like repeats in the C-terminus. These kelch-like repeats promote substrate ubiquitination of bound proteins via interaction of the BTB domain with the CUL3 (cullin 3) component of a cullin-RING E3 ubiquitin ligase (CRL) comp ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000309755
  • ENSP00000312397
  • ENSG00000146021
  • ENST00000506491
  • ENSP00000424828
  • ENST00000508657
  • ENSP00000422099

Symbol
  • KIAA1129
  • PHA2D
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
cell type or tissue
0.64
cell line
0.61
microRNA
0.57
cellular component
0.55


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.55   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 238   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.55   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 238   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (329)
KLHL2
Tbio
Novelty:  0.07279226
p_int:  0.999999999
p_wrong:  1e-9
Score:  0.98
Data Source:  BioPlex,STRINGDB
CUL3
Tbio
Novelty:  0.0028737
Score:  0.999
Data Source:  STRINGDB
RBX1
Tbio
Family:  Enzyme
Novelty:  0.00596986
Score:  0.962
Data Source:  STRINGDB
CUL1
Tbio
Novelty:  0.00244476
Score:  0.954
Data Source:  STRINGDB
KEAP1
Tclin
Novelty:  0.00062812
Score:  0.951
Data Source:  STRINGDB
WNK4
Tbio
Family:  Kinase
Novelty:  0.00795905
Score:  0.944
Data Source:  STRINGDB
CUL5
Tbio
Novelty:  0.00792494
Score:  0.942
Data Source:  STRINGDB
CUL2
Tbio
Novelty:  0.00512916
Score:  0.941
Data Source:  STRINGDB
DET1
Tbio
Novelty:  0.01138079
Score:  0.94
Data Source:  STRINGDB
CAND1
Tbio
Novelty:  0.0196525
Score:  0.938
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Metabolism of proteins
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
2
1
2
56.2
hematocrit
2
2
2
48.5
1
1
0
1.1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
2
56.2
hematocrit
2
48.5
0
1.1
21.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
kelch like family member 3
VGNC:4064
471644
Macaque
kelch like family member 3
713123
Mouse
MGI:2445185
100503085
Rat
RGD:1565218
498697
Dog
kelch like family member 3
VGNC:42463
481523
Species
Name
OMA
EggNOG
Inparanoid
Chimp
kelch like family member 3
Macaque
kelch like family member 3
Mouse
Rat
Dog
kelch like family member 3
Publication Statistics
PubMed Score 33.55
PubMed score by year
PubTator Score 15.22
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title