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Tbio
KLHL3
Kelch-like protein 3

Protein Summary
Description
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of ion transport in the distal nephron (PubMed:14528312, PubMed:22406640, PubMed:23387299, PubMed:23453970, PubMed:23576762, PubMed:23665031). The BCR(KLHL3) complex acts by mediating ubiquitination of WNK4, an inhibitor of potassium channel KCNJ1, leading to WNK4 degradation (PubMed:23387299, PubMed:23453970, PubMed:23576762, PubMed:23665031). The BCR(KLHL3) complex also mediates ubiquitination and degradation of CLDN8, a tight-junction protein required for paracellular chloride transport in the kidney (By similarity). This gene is ubiquitously expressed and encodes a full-length protein which has an N-terminal BTB domain followed by a BACK domain and six kelch-like repeats in the C-terminus. These kelch-like repeats promote substrate ubiquitination of bound proteins via interaction of the BTB domain with the CUL3 (cullin 3) component of a cullin-RING E3 ubiquitin ligase (CRL) comp ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000309755
  • ENSP00000312397
  • ENSG00000146021
  • ENST00000506491
  • ENSP00000424828
  • ENST00000508657
  • ENSP00000422099

Symbol
  • KIAA1129
  • PHA2D
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
cell type or tissue
0.64
cell line
0.61
microRNA
0.57
cellular component
0.55


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.22   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 238   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.22   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 238   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
2
1
2
58.4
hematocrit
1
1
1
48.3
heart failure
1
1
0
1.1
42.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
2
58.4
hematocrit
1
48.3
heart failure
0
1.1
42.7
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (8)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Metabolism of proteins
Gene Ontology Terms (13)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (329)
1 – 10 of 329
KLHL2
Tbio
Novelty: 0.07279226
p_int: 0.999999999
p_wrong: 1e-9
Score: 0.98
Data Source: BioPlex,STRINGDB
CUL3
Tbio
Novelty: 0.0028737
Score: 0.999
Data Source: STRINGDB
RBX1
Tbio
Family: Enzyme
Novelty: 0.00596986
Score: 0.962
Data Source: STRINGDB
CUL1
Tbio
Novelty: 0.00244476
Score: 0.954
Data Source: STRINGDB
KEAP1
Tclin
Novelty: 0.00062812
Score: 0.951
Data Source: STRINGDB
WNK4
Tbio
Family: Kinase
Novelty: 0.00795905
Score: 0.944
Data Source: STRINGDB
CUL5
Tbio
Novelty: 0.00792494
Score: 0.942
Data Source: STRINGDB
CUL2
Tbio
Novelty: 0.00512916
Score: 0.941
Data Source: STRINGDB
DET1
Tbio
Novelty: 0.01138079
Score: 0.94
Data Source: STRINGDB
CAND1
Tbio
Novelty: 0.0196525
Score: 0.938
Data Source: STRINGDB
Publication Statistics
PubMed Score  31.22

PubMed score by year
PubTator Score  15.22

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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