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Tbio
SWAP70
Switch-associated protein 70

Protein Summary
Description
Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of membrane ruffling. Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000318950
  • ENSP00000315630
  • ENSG00000133789

Symbol
  • KIAA0640
  • HSPC321
  • SWAP-70
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.89
kinase perturbation
0.88
molecular function
0.88
virus perturbation
0.85
transcription factor perturbation
0.84


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.43   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 374   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.43   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 374   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diastolic blood pressure
3
3
3
89.6
red blood cell distribution width
2
2
2
83.1
6
4
3
1.1
82.4
mean corpuscular volume
2
2
2
72.9
reticulocyte count
5
1
5
59.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diastolic blood pressure
3
89.6
red blood cell distribution width
2
83.1
3
1.1
82.4
mean corpuscular volume
2
72.9
reticulocyte count
5
59.1
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
switching B-cell complex subunit SWAP70
703651
Mouse
MGI:1298390
20947
Rat
RGD:1305579
293410
Dog
switching B cell complex subunit SWAP70
VGNC:47009
485385
Cow
switching B-cell complex subunit SWAP70
533720
Species
Name
OMA
EggNOG
Inparanoid
Macaque
switching B-cell complex subunit SWAP70
Mouse
Rat
Dog
switching B cell complex subunit SWAP70
Cow
switching B-cell complex subunit SWAP70
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9UH65-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (18)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (29)
1 – 10 of 29
IRF4
Tbio
Family: TF
Novelty: 0.00192973
Score: 0.675
Data Source: STRINGDB
MCF2
Tbio
Novelty: 0.00345951
Score: 0.578
Data Source: STRINGDB
PLEKHG2
Tbio
Novelty: 0.19545538
Score: 0.558
Data Source: STRINGDB
EXOC6
Tbio
Novelty: 0.01886811
Score: 0.552
Data Source: STRINGDB
CD79B
Tclin
Novelty: 0.00227414
Score: 0.542
Data Source: STRINGDB
ITGAL
Tclin
Novelty: 0.00099016
Score: 0.533
Data Source: STRINGDB
CD79A
Tbio
Novelty: 0.00118942
Score: 0.527
Data Source: STRINGDB
ARHGEF11
Tbio
Novelty: 0.01942359
Score: 0.522
Data Source: STRINGDB
PLEKHG4B
Tdark
Novelty: 1.0354449
Score: 0.489
Data Source: STRINGDB
DOCK1
Tbio
Novelty: 0.00867391
Score: 0.485
Data Source: STRINGDB
Publication Statistics
PubMed Score  52.43

PubMed score by year
PubTator Score  28.32

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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