You are using an outdated browser. Please upgrade your browser to improve your experience.

Tdark
ARMCX3
Armadillo repeat-containing X-linked protein 3

Protein Summary
Description
Regulates mitochondrial aggregation and transport in axons in living neurons. May link mitochondria to the TRAK2-kinesin motor complex via its interaction with Miro and TRAK2. Mitochondrial distribution and dynamics is regulated through ARMCX3 protein degradation, which is promoted by PCK and negatively regulated by WNT1. Enhances the SOX10-mediated transactivation of the neuronal acetylcholine receptor subunit alpha-3 and beta-4 subunit gene promoters. This gene encodes a member of the ALEX family of proteins which may play a role in tumor suppression. The encoded protein contains a potential N-terminal transmembrane domain and a single Armadillo (arm) repeat. Other proteins containing the arm repeat are involved in development, maintenance of tissue integrity, and tumorigenesis. This gene is closely localized with other family members on the X chromosome. Three transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000341189
  • ENSP00000340672
  • ENSG00000102401
  • ENST00000471229
  • ENSP00000454483
  • ENST00000537169
  • ENSP00000439032

Symbol
  • ALEX3
  • ALEX3
  • GASP6
  • dJ545K15.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.96
kinase perturbation
0.71
PubMedID
0.71
tissue sample
0.69
disease perturbation
0.62


Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.72   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 224   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.72   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 224   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
armadillo repeat containing, X-linked 3
704035
Mouse
MGI:1918953
71703
Rat
RGD:1549739
367902
Dog
armadillo repeat containing X-linked 3
VGNC:54661
492022
Horse
armadillo repeat containing, X-linked 3
100057749
Species
Name
OMA
EggNOG
Inparanoid
Macaque
armadillo repeat containing, X-linked 3
Mouse
Rat
Dog
armadillo repeat containing X-linked 3
Horse
armadillo repeat containing, X-linked 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9UH62-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (4)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (31)
1 – 10 of 31
VWA5A
Tbio
Novelty:  0.0802354
p_int:  0.999255505
p_ni:  0.000744495
Data Source:  BioPlex
CLEC2B
Tbio
Novelty:  0.06581244
p_int:  0.96862927
p_ni:  0.031370729
p_wrong:  1e-9
Data Source:  BioPlex
HCCS
Tbio
Family:  Enzyme
Novelty:  0.0022585
p_int:  0.96626431
p_ni:  0.03373569
Score:  0.243
Data Source:  BioPlex,STRINGDB
CCDC59
Tbio
Novelty:  0.05894885
p_int:  0.948922962
p_ni:  0.051077038
Data Source:  BioPlex
RANBP6
Tdark
Novelty:  0.75714796
p_int:  0.943632307
p_ni:  0.056367693
Score:  0.588
Data Source:  BioPlex,STRINGDB
BRAF
Tclin
Family:  Kinase
Novelty:  0.00253795
p_int:  0.943261542
p_ni:  0.056738458
Data Source:  BioPlex
MAF1
Tbio
Family:  Enzyme
Novelty:  0.01060279
p_int:  0.939892046
p_ni:  0.060107954
Score:  0.189
Data Source:  BioPlex,STRINGDB
TMEM206
Tdark
Novelty:  0.17311172
p_int:  0.894856698
p_ni:  0.105143302
Data Source:  BioPlex
VTN
Tbio
Family:  TF
Novelty:  0.00046861
p_int:  0.871280645
p_ni:  0.128719355
Data Source:  BioPlex
FBL
Tbio
Family:  Enzyme
Novelty:  0.00080634
p_int:  0.846931963
p_ni:  0.153068037
Data Source:  BioPlex
Publication Statistics
PubMed Score  4.72

PubMed score by year
PubTator Score  2.58

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer