You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
APOBEC3B
DNA dC->dU-editing enzyme APOBEC-3B

Protein Summary
Description
DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single-or double-stranded RNA. Exhibits antiviral activity against simian immunodeficiency virus (SIV), hepatitis B virus (HBV) and human T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000333467
  • ENSP00000327459
  • ENSG00000179750
  • ENST00000335760
  • ENSP00000338897
  • ENST00000407298
  • ENSP00000385068

Symbol
  • A3B
  • ARP4
  • ARCD3
  • PHRBNL
  • APOBEC1L
  • bK150C2.2
  • DJ742C19.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.88
PubMedID
0.84
histone modification site profile
0.81
interacting protein
0.79
transcription factor perturbation
0.68


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 163.78   (req: < 5)
Gene RIFs: 93   (req: <= 3)
Antibodies: 161   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 163.78   (req: >= 5)
Gene RIFs: 93   (req: > 3)
Antibodies: 161   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (1)
1 – 1 of 1
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
apolipoprotein B mRNA editing enzyme catalytic subunit 3B
VGNC:12807
743891
Species
Name
OMA
EggNOG
Inparanoid
Chimp
apolipoprotein B mRNA editing enzyme catalytic subunit 3B
Protein Data Bank (9)
1 – 5 of 9
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (5)
Formation of the Editosome (R-HSA-75094)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Formation of the Editosome
Reactome
Metabolism of RNA
Reactome
mRNA Editing
Reactome
mRNA Editing: C to U Conversion
Name
Explore in Pharos
Explore in Source
Formation of the Editosome
Metabolism of RNA
mRNA Editing
mRNA Editing: C to U Conversion
Gene Ontology Terms (11)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (60)
1 – 10 of 60
LARP4B
Tbio
Novelty: 0.11363794
p_int: 0.999996725
p_ni: 4.46e-7
p_wrong: 0.000002829
Data Source: BioPlex
ELAVL2
Tbio
Novelty: 0.00370708
p_int: 0.996506184
p_ni: 3.53e-7
p_wrong: 0.003493463
Score: 0.19
Data Source: BioPlex,STRINGDB
APOBEC4
Tdark
Novelty: 0.13240154
Score: 0.977
Data Source: STRINGDB
A1CF
Tbio
Novelty: 0.04151936
Score: 0.926
Data Source: STRINGDB
APOBEC1
Tbio
Novelty: 0.00622042
Score: 0.925
Data Source: STRINGDB
APOBEC3H
Tbio
Novelty: 0.01600106
Score: 0.92
Data Source: STRINGDB
APOBEC2
Tbio
Novelty: 0.03447716
Score: 0.92
Data Source: STRINGDB
APOBEC3C
Tbio
Novelty: 0.00882074
Score: 0.909
Data Source: STRINGDB
APOBEC3A
Tbio
Novelty: 0.00982993
Score: 0.909
Data Source: STRINGDB
COX5B
Tbio
Family: Enzyme
Novelty: 0.01729026
Score: 0.819
Data Source: STRINGDB
Publication Statistics
PubMed Score  163.78

PubMed score by year
PubTator Score  143.26

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer