Tbio APOBEC3B DNA dC->dU-editing enzyme APOBEC-3B

Protein Summary

Description

DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single-or double-stranded RNA. Exhibits antiviral activity against simian immunodeficiency virus (SIV), hepatitis B virus (HBV) and human T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons. This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control. A hybrid gene results from the deletion of approximately 29.5 kb of sequence between this gene, APOBEC3B, and the adjacent gene APOBEC3A. The breakpoints of the deletion are within the two genes, so the deletion allele is predicted to have the promoter and coding region of APOBEC3A, but the 3' UTR of APOBEC3B. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012]

Uniprot Accession IDs

• Q9UH17
• B0QYD2
• O95618
• Q20WL1
• Q5IFJ4
• Q7Z2N3
• Q7Z6D6
• Q9UE74
• A3B

Gene Name

• APOBEC3B

Ensembl ID

• ENST00000333467
• ENSP00000327459
• ENSG00000179750
• ENST00000335760
• ENSP00000338897
• ENST00000407298
• ENSP00000385068

Symbol

• A3B
• ARP4
• ARCD3
• PHRBNL
• APOBEC1L
• bK150C2.2
• DJ742C19.2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.88
PubMedID	0.84
histone modification site profile	0.81
interacting protein	0.79
transcription factor perturbation	0.68

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Dna Dc->du-editing Enzyme Apobec-3b

Protein / Hydrolase / Deaminase / Dna Dc->du-editing Enzyme Apobec-3b

DTO Classes

Protein / Enzyme / Hydrolase / Deaminase / Dna Dc->du-editing Enzyme Apobec-3b

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 194.9   (req: < 5)

Gene RIFs: 164   (req: <= 3)

Antibodies: 161   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 194.9   (req: >= 5)

Gene RIFs: 164   (req: > 3)

Antibodies: 161   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0