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Tbio
SEPT3
Neuronal-specific septin-3

Protein Summary
Description
Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). This gene belongs to the septin family of GTPases. Members of this family are required for cytokinesis. Expression is upregulated by retinoic acid in a human teratocarcinoma cell line. The specific function of this gene has not been determined. Alternative splicing of this gene results in several transcript variants encoding different isoforms. [provided by RefSeq, May 2018]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000396417
  • ENSP00000379695
  • ENSG00000100167
  • ENST00000396425
  • ENSP00000379703
  • ENST00000396426
  • ENSP00000379704

Symbol
  • SEP3
  • SEP3
  • bK250D10.3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.84
molecular function
0.76
cell type or tissue
0.63
disease perturbation
0.62
histone modification site profile
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 115.11   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 210   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 115.11   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 210   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cognitive function measurement
2
1
2
88.3
self reported educational attainment
1
1
1
85.7
intelligence
2
2
0
6
80.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cognitive function measurement
2
88.3
self reported educational attainment
1
85.7
intelligence
0
6
80.1
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Protein-Protein Interactions (54)
1 – 10 of 54
SEPT7
Tbio
Novelty: 0.00554708
p_int: 1
Score: 0.933
Data Source: BioPlex,STRINGDB
SEPT2
Tbio
Novelty: 0.01047916
p_int: 1
Score: 0.914
Data Source: BioPlex,STRINGDB
SEPT6
Tbio
Novelty: 0.00885503
p_int: 1
Score: 0.892
Data Source: BioPlex,STRINGDB
SEPT10
Tbio
Novelty: 0.14834834
p_int: 1
Score: 0.846
Data Source: BioPlex,STRINGDB
SEPT1
Tdark
Novelty: 0.04450119
p_int: 0.999999825
p_ni: 1.75e-7
Score: 0.919
Data Source: BioPlex,STRINGDB
SEPT8
Tbio
Novelty: 0.01431499
p_int: 0.999999212
p_ni: 7.88e-7
Score: 0.856
Data Source: BioPlex,STRINGDB
MRPL12
Tbio
Novelty: 0.10646542
p_int: 0.999998561
p_ni: 0.000001439
Score: 0.215
Data Source: BioPlex,STRINGDB
CDC42EP4
Tdark
Novelty: 0.27965905
p_int: 0.999995839
p_ni: 0.000004161
Score: 0.877
Data Source: BioPlex,STRINGDB
SEPT5
Tbio
Novelty: 0.01670991
p_int: 0.999988071
p_ni: 0.00001191
p_wrong: 1.9e-8
Score: 0.938
Data Source: BioPlex,STRINGDB
SEPT14
Tbio
Novelty: 0.07155096
p_int: 0.999985685
p_ni: 3e-9
p_wrong: 0.000014312
Score: 0.835
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  115.11

PubMed score by year
PubTator Score  85.3

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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