Tbio NDRG3 Protein NDRG3

Protein Classes

PANTHER Classes

Protein / ... / Serine Protease / Protein Ndrg3

Protein Summary

Uniprot Accession IDs

• Q9UGV2
• A2A2S8
• E1P5U7
• E1P5U8
• Q5TH32
• Q96PL8
• Q96SM2
• Q9BXY7
• Q9H3N7
• Q9H411
• Q9H8J6

Gene Name

• NDRG3

Ensembl ID

• ENST00000349004
• ENSP00000345292
• ENSG00000101079
• ENST00000359675
• ENSP00000352703

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.97
transcription factor perturbation	0.94
tissue	0.71
histone modification site profile	0.69
disease perturbation	0.68

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.84   (req: < 5)

Gene RIFs: 13   (req: <= 3)

Antibodies: 125   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.84   (req: >= 5)

Gene RIFs: 13   (req: > 3)

Antibodies: 125   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Gene Ontology Terms (6)

Components (2)

Processes (4)

Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
cytoplasm	Inferred from Direct Assay (IDA)	UniProtKB
extracellular exosome	Inferred from High Throughput Direct Assay (HDA)	UniProtKB

Protein-Protein Interactions (27)

Explore Interacting Targets

1 – 10 of 27

• See Interactions on String-DB

FXYD1

Tbio

Family: IC

Novelty: 0.00176593

p_int: 0.999998347

p_ni: 4.4e-7

p_wrong: 0.000001214

Score: 0.355

Data Source: BioPlex,STRINGDB

PICK1

Tbio

Novelty: 0.00686801

p_int: 0.999794895

p_ni: 0.000006366

p_wrong: 0.000198739

Score: 0.209

Data Source: BioPlex,STRINGDB

TUSC3

Tbio

Novelty: 0.01081706

p_int: 0.998855105

p_ni: 0.000006758

p_wrong: 0.001138137

Score: 0.239

Data Source: BioPlex,STRINGDB

PRSS21

Tbio

Family: Enzyme

Novelty: 0.00474208

p_int: 0.816980553

p_ni: 0.000054904

p_wrong: 0.182964544

Data Source: BioPlex

STK38L

Tchem

Family: Kinase

Novelty: 0.054716

Score: 0.908

Data Source: STRINGDB

TARDBP

Tbio

Novelty: 0.00206735

Score: 0.866

Data Source: STRINGDB

CSTF1

Tbio

Novelty: 0.11966948

Score: 0.84

Data Source: STRINGDB

NPEPL1

Tdark

Family: Enzyme

Novelty: 1.23076923

Score: 0.807

Data Source: STRINGDB

HDHD3

Tdark

Family: Enzyme

Novelty: 2.25

Score: 0.734

Data Source: STRINGDB

EDEM2

Tbio

Family: Enzyme

Novelty: 0.16891213

Score: 0.69

Data Source: STRINGDB

Publication Statistics

PubMed Score  15.84

PubMed score by year

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PubTator Score  11.85

PubTator score by year

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Amino Acid Sequence

Residue Counts

Sequence

MDELQDVQLTEIKPLLNDKNGTRNFQDFDCQEHDIETTHGVVHVTIRGLPKGNRPVILTYHDIGLNHKSC

1-70

FNAFFNFEDMQEITQHFAVCHVDAPGQQEGAPSFPTGYQYPTMDELAEMLPPVLTHLSLKSIIGIGVGAG

70-140

AYILSRFALNHPELVEGLVLINVDPCAKGWIDWAASKLSGLTTNVVDIILAHHFGQEELQANLDLIQTYR

140-210

MHIAQDINQDNLQLFLNSYNGRRDLEIERPILGQNDNKSKTLKCSTLLVVGDNSPAVEAVVECNSRLNPI

210-280

NTTLLKMADCGGLPQVVQPGKLTEAFKYFLQGMGYIPSASMTRLARSRTHSTSSSLGSGESPFSRSVTSN

280-350

QSDGTQESCESPDVLDRHQTMEVSC

350-375

MDELQDVQLTEIKPLLNDKNGTRNFQDFDCQEHDIETTHGVVHVTIRGLPKGNRPVILTYHDIGLNHKSCFNAFFNFEDMQEITQHFAVCHVDAPGQQEGAPSFPTGYQYPTMDELAEMLPPVLTHLSLKSIIGIGVGAGAYILSRFALNHPELVEGLVLINVDPCAKGWIDWAASKLSGLTTNVVDIILAHHFGQEELQANLDLIQTYRMHIAQDINQDNLQLFLNSYNGRRDLEIERPILGQNDNKSKTLKCSTLLVVGDNSPAVEAVVECNSRLNPINTTLLKMADCGGLPQVVQPGKLTEAFKYFLQGMGYIPSASMTRLARSRTHSTSSSLGSGESPFSRSVTSNQSDGTQESCESPDVLDRHQTMEVSC

Find similar targets by:

Uniprot Keyword

Acetylation
Alternative splicing
Complete proteome
Phosphoprotein
Reference proteome