You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
HMGXB4
HMG domain-containing protein 4

Protein Summary
Description
Negatively regulates Wnt/beta-catenin signaling during development. High mobility group (HMG) proteins are nonhistone chromosomal proteins. See HMG2 (MIM 163906) for additional information on HMG proteins.[supplied by OMIM, Nov 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000216106
  • ENSP00000216106
  • ENSG00000100281

Symbol
  • HMG2L1
  • HMGBCG
  • HMG2L1
  • HMGBCG
  • THC211630
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.84
transcription factor binding site profile
0.77
transcription factor perturbation
0.68
histone modification site profile
0.63
microRNA
0.6


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.71   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 158   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.71   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 158   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
2
3
4
74.6
BMI-adjusted waist-hip ratio
2
2
2
72.1
low density lipoprotein cholesterol measurement
2
2
2
50.6
hip circumference
1
2
2
43.9
platelet count
1
1
1
39.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
4
74.6
BMI-adjusted waist-hip ratio
2
72.1
low density lipoprotein cholesterol measurement
2
50.6
hip circumference
2
43.9
platelet count
1
39.6
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
HMG-box containing 4
VGNC:5269
458788
Macaque
HMG-box containing 4
717471
Mouse
MGI:1918073
70823
Rat
RGD:1305783
307667
Dog
HMG-box containing 4
VGNC:41717
481285
Species
Name
OMA
EggNOG
Inparanoid
Chimp
HMG-box containing 4
Macaque
HMG-box containing 4
Mouse
Rat
Dog
HMG-box containing 4
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9UGU5-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (5)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (49)
1 – 10 of 49
BPTF
Tchem
Family:  Epigenetic
Novelty:  0.00826037
Score:  0.996
Data Source:  STRINGDB
RBBP4
Tbio
Novelty:  0.01062843
Score:  0.979
Data Source:  STRINGDB
NCOR1
Tchem
Family:  TF
Novelty:  0.0021926
Score:  0.945
Data Source:  STRINGDB
BAP18
Tbio
Novelty:  0.31948142
Score:  0.944
Data Source:  STRINGDB
CECR2
Tchem
Family:  Epigenetic
Novelty:  0.04949741
Score:  0.942
Data Source:  STRINGDB
SMARCA1
Tbio
Novelty:  0.00452148
Score:  0.929
Data Source:  STRINGDB
SMARCA5
Tbio
Novelty:  0.00518484
Score:  0.92
Data Source:  STRINGDB
TOM1
Tbio
Novelty:  0.00725956
Score:  0.91
Data Source:  STRINGDB
CHRAC1
Tbio
Novelty:  0.17492099
Score:  0.902
Data Source:  STRINGDB
MCM5
Tbio
Novelty:  0.00716583
Score:  0.902
Data Source:  STRINGDB
Publication Statistics
PubMed Score  4.71

PubMed score by year
PubTator Score  3.03

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: