You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
TCF20
Transcription factor 20

Protein Summary
Description
Transcriptional activator that binds to the regulatory region of MMP3 and thereby controls stromelysin expression. It stimulates the activity of various transcriptional activators such as JUN, SP1, PAX6 and ETS1, suggesting a function as a coactivator. This gene encodes a transcription factor that recognizes the platelet-derived growth factor-responsive element in the matrix metalloproteinase 3 promoter. The encoded protein is thought to be a transcriptional coactivator, enhancing the activity of transcription factors such as JUN and SP1. Mutations in this gene are associated with autism spectrum disorders. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000335626
  • ENSP00000335561
  • ENSG00000100207
  • ENST00000359486
  • ENSP00000352463
  • ENST00000574943
  • ENSP00000460328
  • ENSG00000262024
  • ENST00000576946
  • ENSP00000460587
  • ENST00000619505
  • ENSP00000478503
  • ENSG00000276461
  • ENST00000621408
  • ENSP00000483199
  • ENST00000626486
  • ENSP00000487465
  • ENSG00000280467
  • ENST00000626726
  • ENSP00000487302
  • ENSG00000281897
  • ENST00000628774
  • ENSP00000487296
  • ENST00000629538
  • ENSP00000486940
  • ENST00000634489
  • ENSP00000489099
  • ENSG00000282892
  • ENST00000634616
  • ENSP00000489614
  • ENSG00000283026
  • ENST00000635146
  • ENSP00000489215
  • ENST00000635421
  • ENSP00000489006
  • ENST00000636799
  • ENSP00000490305
  • ENSG00000283681
  • ENST00000637355
  • ENSP00000489734

Symbol
  • KIAA0292
  • SPBP
  • AR1
  • SPBP
  • TCF-20
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
0.96
disease perturbation
0.95
kinase perturbation
0.95
ligand (protein) perturbation
0.83
tissue sample
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1588.44   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 66   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1588.44   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 66   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0