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Tbio
SUSD2
Sushi domain-containing protein 2

Protein Summary
Description
May be a cytokine receptor for C10ORF99. May be a tumor suppressor; together with C10ORF99 has a growth inhibitory effect on colon cancer cells which includes G1 cell cycle arrest (PubMed:25351403). May play a role in breast tumorigenesis (PubMed:23131994).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000358321
  • ENSP00000351075
  • ENSG00000099994

Symbol
  • W5C5
  • BK65A6.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.7
gene perturbation
0.65
cell type or tissue
0.61
tissue sample
0.6
protein domain
0.58


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.9   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 317   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.9   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 317   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
1
7
7
97
monocyte count
2
2
2
93.4
lymphocyte count
2
2
2
83.9
eosinophil count
3
1
3
81.1
myeloid white cell count
1
1
1
75.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
7
97
monocyte count
2
93.4
lymphocyte count
2
83.9
eosinophil count
3
81.1
myeloid white cell count
1
75.6
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
sushi domain containing 2
720248
Mouse
MGI:1918983
71733
Rat
RGD:1308595
294335
Dog
sushi domain containing 2
VGNC:46998
486402
Horse
sushi domain containing 2
VGNC:23772
100053323
Species
Name
OMA
EggNOG
Inparanoid
Macaque
sushi domain containing 2
Mouse
Rat
Dog
sushi domain containing 2
Horse
sushi domain containing 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9UGT4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (8)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (27)
1 – 10 of 27
ISM2
Tdark
Novelty:  0.03660434
Score:  0.771
Data Source:  STRINGDB
TMEM72
Tdark
Novelty:  1.02661278
Score:  0.616
Data Source:  STRINGDB
TMEM100
Tbio
Novelty:  0.07486407
Score:  0.605
Data Source:  STRINGDB
GPR15L
Tbio
Novelty:  0.01327039
Score:  0.57
Data Source:  STRINGDB
ISM1
Tbio
Novelty:  0.03082946
Score:  0.561
Data Source:  STRINGDB
GJB3
Tbio
Novelty:  0.00612314
Score:  0.541
Data Source:  STRINGDB
AK7
Tbio
Family:  Enzyme
Novelty:  0.0283556
Score:  0.532
Data Source:  STRINGDB
F3
Tchem
Novelty:  0.00006457
Score:  0.529
Data Source:  STRINGDB
RELT
Tbio
Novelty:  0.07977949
Score:  0.527
Data Source:  STRINGDB
LRRC75B
Tdark
Novelty:  2.22222222
Score:  0.509
Data Source:  STRINGDB
Publication Statistics
PubMed Score  35.90

PubMed score by year
PubTator Score  15.09

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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