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Tbio
SEC63
Translocation protein SEC63 homolog

Protein Classes
Protein Summary
Description
Mediates cotranslational and post-translational transport of certain precursor polypeptides across endoplasmic reticulum (ER) (PubMed:22375059, PubMed:29719251). Proposed to play an auxiliary role in recognition of precursors with short and apolar signal peptides. May cooperate with SEC62 and HSPA5/BiP to facilitate targeting of small presecretory proteins into the SEC61 channel-forming translocon complex, triggering channel opening for polypeptide translocation to the ER lumen (PubMed:29719251). Required for efficient PKD1/Polycystin-1 biogenesis and trafficking to the plasma membrane of the primary cilia (By similarity). The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The protein encoded by this gene and SEC62 protein are found to be associated with ribosome-free SEC61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 com ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369002
  • ENSP00000357998
  • ENSG00000025796

Symbol
  • SEC63L
  • ERdj2
  • PCLD2
  • SEC63L
  • DNAJC23
  • PRO2507
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
transcription factor perturbation
0.98
hub protein
0.92
disease perturbation
0.9
protein domain
0.73


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 102.96   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 121   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 102.96   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 121   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte percentage of leukocytes
2
2
2
57.1
neutrophil percentage of leukocytes
2
2
2
43.9
donor genotype effect measurement
1
1
0
1.5
35
mathematical ability
1
1
1
35
renal transplant outcome measurement
1
1
0
1.5
35
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte percentage of leukocytes
2
57.1
neutrophil percentage of leukocytes
2
43.9
donor genotype effect measurement
0
1.5
35
mathematical ability
1
35
renal transplant outcome measurement
0
1.5
35
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SEC63 homolog, protein translocation regulator
VGNC:3698
462915
Macaque
SEC63 homolog, protein translocation regulator
698863
Mouse
MGI:2155302
140740
Rat
RGD:1304984
309858
Horse
SEC63 homolog, protein translocation regulator
VGNC:51078
100072096
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SEC63 homolog, protein translocation regulator
Macaque
SEC63 homolog, protein translocation regulator
Mouse
Rat
Horse
SEC63 homolog, protein translocation regulator
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9UGP8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (17)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (189)
1 – 10 of 189
STEAP3
Tbio
Family:  Enzyme
Novelty:  0.02042104
p_int:  0.974307954
p_ni:  0.025650991
p_wrong:  0.000041055
Data Source:  BioPlex
YIPF3
Tbio
Novelty:  0.12021667
p_int:  0.967792206
p_ni:  0.032207794
Data Source:  BioPlex
TBL2
Tbio
Novelty:  0.04754985
p_int:  0.95008552
p_ni:  0.049914474
p_wrong:  6e-9
Data Source:  BioPlex
HTR2C
Tclin
Family:  GPCR
Novelty:  0.00074287
p_int:  0.949912579
p_ni:  0.050087421
Data Source:  BioPlex
ARFGAP1
Tbio
Family:  Enzyme
Novelty:  0.02654081
p_int:  0.90019169
p_ni:  0.099808306
p_wrong:  4e-9
Score:  0.304
Data Source:  BioPlex,STRINGDB
TSPAN31
Tbio
Novelty:  0.13580467
p_int:  0.893064763
p_ni:  0.106935237
Data Source:  BioPlex
BIN3
Tbio
Novelty:  0.02034119
p_int:  0.889117365
p_ni:  0.110882635
Score:  0.187
Data Source:  BioPlex,STRINGDB
GPRC5B
Tbio
Family:  GPCR
Novelty:  0.05128765
p_int:  0.863959704
p_ni:  0.136040296
Score:  0.188
Data Source:  BioPlex,STRINGDB
POLE4
Tdark
Family:  Enzyme
Novelty:  0.23346084
p_int:  0.86025287
p_ni:  0.13974713
Data Source:  BioPlex
KCNE1
Tchem
Family:  IC
Novelty:  0.0015463
p_int:  0.852252715
p_ni:  0.147747285
Data Source:  BioPlex
Publication Statistics
PubMed Score  102.96

PubMed score by year
PubTator Score  26.19

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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