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Tbio
LIMD1
LIM domain-containing protein 1

Protein Summary
Description
Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing and is essential for P-body formation and integrity. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Acts as a transcriptional corepressor for SNAI1- and SNAI2/SLUG-dependent repression of E-cadherin transcription. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1. Inhibits E2F-mediated transcription, and suppresses the expression of the majority of genes with E2F1-responsive elements. Regulates osteoblast development, function, differentiation and stress osteoclastogenesis. Enhances the ability of TRA ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000273317
  • ENSP00000273317
  • ENSG00000144791
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.94
biological process
0.9
disease perturbation
0.9
virus perturbation
0.88
transcription factor binding site profile
0.75


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.39   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 197   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.39   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 197   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
2
2
3
91.1
macrophage inflammatory protein 1b measurement
1
1
1
79.3
ganglion cell inner plexiform layer thickness measurement
1
1
1
76
blood protein measurement
1
1
1
71.6
viral load
1
1
1
66
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
3
91.1
macrophage inflammatory protein 1b measurement
1
79.3
ganglion cell inner plexiform layer thickness measurement
1
76
blood protein measurement
1
71.6
viral load
1
66
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
LIM domains containing 1
VGNC:1860
471102
Macaque
LIM domains containing 1
714169
Mouse
MGI:1352502
29806
Rat
RGD:1309830
316101
Dog
LIM domains containing 1
VGNC:42679
100856566
Species
Name
OMA
EggNOG
Inparanoid
Chimp
LIM domains containing 1
Macaque
LIM domains containing 1
Mouse
Rat
Dog
LIM domains containing 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9UGP4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (168)
Cellular response to hypoxia (R-HSA-1234174)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular response to hypoxia
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Name
Explore in Pharos
Explore in Source
Cellular response to hypoxia
Cellular responses to external stimuli
Cellular responses to stress
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Gene Ontology Terms (29)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (130)
1 – 10 of 130
PPP2R3A
Tbio
Family:  Enzyme
Novelty:  0.0350873
p_int:  0.999999556
p_ni:  4.44e-7
p_wrong:  1e-9
Score:  0.179
Data Source:  BioPlex,STRINGDB
SLC27A3
Tbio
Family:  Transporter
Novelty:  0.1037612
p_int:  0.999987423
p_ni:  0.000012577
Data Source:  BioPlex
GOLGA4
Tbio
Novelty:  0.01363253
p_int:  0.999882706
p_ni:  0.000117289
p_wrong:  5e-9
Score:  0.198
Data Source:  BioPlex,STRINGDB
PHYHIP
Tdark
Family:  Enzyme
Novelty:  0.25773185
p_int:  0.999527483
p_ni:  0.000472456
p_wrong:  6.1e-8
Score:  0.71
Data Source:  BioPlex,STRINGDB
LPXN
Tbio
Novelty:  0.00796678
p_int:  0.999477405
p_ni:  0.000522595
Score:  0.242
Data Source:  BioPlex,STRINGDB
FBXO10
Tbio
Novelty:  0.18324932
p_int:  0.999470086
p_ni:  0.000529875
p_wrong:  4e-8
Data Source:  BioPlex
ZNF576
Tdark
Family:  TF
Novelty:  13.18548387
p_int:  0.999177807
p_ni:  0.000821747
p_wrong:  4.46e-7
Score:  0.33
Data Source:  BioPlex,STRINGDB
ZNF843
Tdark
p_int:  0.99888956
p_ni:  0.001110439
p_wrong:  1e-9
Score:  0.208
Data Source:  BioPlex,STRINGDB
LMO2
Tbio
Novelty:  0.0038279
p_int:  0.997305604
p_ni:  0.002694396
Data Source:  BioPlex
TEKT3
Tbio
Novelty:  0.06646482
p_int:  0.997053254
p_ni:  0.002946255
p_wrong:  4.92e-7
Score:  0.159
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  31.39

PubMed score by year
PubTator Score  15.58

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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