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Tclin
PARP2
Poly [ADP-ribose] polymerase 2

Protein Summary
Description
Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism (PubMed:10364231, PubMed:28190768). This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks (PubMed:10364231). Mediates serine ADP-ribosylation of target proteins following interaction with HPF1; HPF1 conferring serine specificity (PubMed:28190768). This gene encodes poly(ADP-ribosyl)transferase-like 2 protein, which contains a catalytic domain and is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. The basic residues within the N-terminal region of this protein may bear pote ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000250416
  • ENSP00000250416
  • ENSG00000129484
  • ENST00000429687
  • ENSP00000392972

Symbol
  • ADPRT2
  • ADPRTL2
  • ARTD2
  • ADPRT2
  • PARP-2
  • ADPRTL2
  • ADPRTL3
  • pADPRT-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.99
kinase perturbation
0.97
histone modification site profile
0.84
virus perturbation
0.76
tissue sample
0.73


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 168.05   (req: < 5)
Gene RIFs: 29   (req: <= 3)
Antibodies: 273   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 168.05   (req: >= 5)
Gene RIFs: 29   (req: > 3)
Antibodies: 273   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 97
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
poly(ADP-ribose) polymerase 2
VGNC:3346
465197
Macaque
poly(ADP-ribose) polymerase 2
701955
Mouse
MGI:1341112
11546
Rat
RGD:1310568
290027
Dog
poly(ADP-ribose) polymerase 2
VGNC:54219
475392
Species
Name
OMA
EggNOG
Inparanoid
Chimp
poly(ADP-ribose) polymerase 2
Macaque
poly(ADP-ribose) polymerase 2
Mouse
Rat
Dog
poly(ADP-ribose) polymerase 2
Protein Structure (11 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9UGN5-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 11
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (47)
Base Excision Repair (R-HSA-73884)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Base Excision Repair
Reactome
DNA Damage Recognition in GG-NER
Reactome
DNA Double-Strand Break Repair
Reactome
DNA Repair
Reactome
Dual Incision in GG-NER
Name
Explore in Pharos
Explore in Source
Base Excision Repair
DNA Damage Recognition in GG-NER
DNA Double-Strand Break Repair
DNA Repair
Dual Incision in GG-NER
Gene Ontology Terms (15)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (210)
1 – 10 of 210
RNF146
Tbio
Family: Enzyme
Novelty: 0.05463359
p_int: 0.999997098
p_ni: 0.000002902
Score: 0.797
Data Source: BioPlex,STRINGDB
POLB
Tchem
Family: Enzyme
Novelty: 0.00145102
p_int: 0.9999918
p_ni: 0.0000082
Score: 0.972
Data Source: BioPlex,STRINGDB
H2AFX
Tbio
Novelty: 0.00048694
p_int: 0.999991005
p_ni: 0.000008995
Score: 0.612
Data Source: BioPlex,STRINGDB
CHD1L
Tbio
Family: Enzyme
Novelty: 0.00980287
p_int: 0.999982555
p_ni: 0.000017445
Score: 0.975
Data Source: BioPlex,STRINGDB
APLF
Tbio
Novelty: 0.01347476
p_int: 0.999977284
p_ni: 0.000022716
Score: 0.822
Data Source: BioPlex,STRINGDB
HIST1H2BA
Tbio
Novelty: 0.02431803
p_int: 0.999950601
p_ni: 0.000049397
p_wrong: 2e-9
Score: 0.326
Data Source: BioPlex,STRINGDB
XPC
Tbio
Novelty: 0.00775175
p_int: 0.999949408
p_ni: 0.000050592
Score: 0.981
Data Source: BioPlex,STRINGDB
XRCC6
Tbio
Novelty: 0.00127955
p_int: 0.999935167
p_ni: 0.000064832
Score: 0.942
Data Source: BioPlex,STRINGDB
C1orf174
Tdark
Novelty: 4.20172485
p_int: 0.999870608
p_ni: 0.000129392
Data Source: BioPlex
MACROD1
Tbio
Family: Enzyme
Novelty: 0.03610474
p_int: 0.999709369
p_ni: 0.000290631
Score: 0.752
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  168.05

PubMed score by year
PubTator Score  113.6

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer